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Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway.

Zhao W, Kitidis C, Fleming MD, Lodish HF, Ghaffari S.

Blood. 2006 Feb 1;107(3):907-15. Epub 2005 Oct 4.


AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.

Ghaffari S, Kitidis C, Zhao W, Marinkovic D, Fleming MD, Luo B, Marszalek J, Lodish HF.

Blood. 2006 Mar 1;107(5):1888-91. Epub 2005 Oct 27.


Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation.

Bouscary D, Pene F, Claessens YE, Muller O, Chrétien S, Fontenay-Roupie M, Gisselbrecht S, Mayeux P, Lacombe C.

Blood. 2003 May 1;101(9):3436-43. Epub 2002 Dec 27.


Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.

Tong W, Zhang J, Lodish HF.

Blood. 2005 Jun 15;105(12):4604-12. Epub 2005 Feb 10.


Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.

Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S.

Mol Cell Biol. 2005 Sep;25(17):7412-22.


Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors.

Uddin S, Kottegoda S, Stigger D, Platanias LC, Wickrema A.

Biochem Biophys Res Commun. 2000 Aug 18;275(1):16-9.


Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors.

Hisakawa H, Sugiyama D, Nishijima I, Xu MJ, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K.

Blood. 2001 Dec 15;98(13):3618-25.


Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.

Myklebust JH, Blomhoff HK, Rusten LS, Stokke T, Smeland EB.

Exp Hematol. 2002 Sep;30(9):990-1000.


The signaling pathways of erythropoietin and interferon-gamma differ in preventing the apoptosis of mature erythroid progenitor cells.

Paiboonsukwong K, Choi I, Matsushima T, Abe Y, Nishimura J, Winichagoon P, Fucharoen S, Nawata H, Muta K.

Int J Hematol. 2003 Dec;78(5):421-8.


Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.

Slavova-Azmanova NS, Kucera N, Satiaputra J, Stone L, Magno A, Maxwell MJ, Quilici C, Erber W, Klinken SP, Hibbs ML, Ingley E.

Blood. 2013 Jul 11;122(2):262-71. doi: 10.1182/blood-2012-10-463158. Epub 2013 May 21.


Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation.

Buck I, Morceau F, Cristofanon S, Heintz C, Chateauvieux S, Reuter S, Dicato M, Diederich M.

Biochem Pharmacol. 2008 Nov 15;76(10):1229-39. doi: 10.1016/j.bcp.2008.08.025. Epub 2008 Sep 2.


Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn.

Tilbrook PA, Palmer GA, Bittorf T, McCarthy DJ, Wright MJ, Sarna MK, Linnekin D, Cull VS, Williams JH, Ingley E, Schneider-Mergener J, Krystal G, Klinken SP.

Cancer Res. 2001 Mar 15;61(6):2453-8.


Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin.

Dunlop EA, Percy MJ, Boland MP, Maxwell AP, Lappin TR.

Neurodegener Dis. 2006;3(1-2):94-100.


A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution.

Halupa A, Bailey ML, Huang K, Iscove NN, Levy DE, Barber DL.

Blood. 2005 Jan 15;105(2):552-61. Epub 2004 Jun 22.


Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors.

Ghaffari S, Kitidis C, Fleming MD, Neubauer H, Pfeffer K, Lodish HF.

Blood. 2001 Nov 15;98(10):2948-57.


Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.

Wu H, Klingmüller U, Acurio A, Hsiao JG, Lodish HF.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1806-10.


JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.

Shi J, Yuan B, Hu W, Lodish H.

Exp Hematol. 2016 Nov;44(11):1044-1058.e5. doi: 10.1016/j.exphem.2016.07.010. Epub 2016 Jul 26.


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