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Isc1 regulates sphingolipid metabolism in yeast mitochondria.

Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA.

Biochim Biophys Acta. 2007 Nov;1768(11):2849-61. Epub 2007 Aug 10.


Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.

Cowart LA, Hannun YA.

J Biol Chem. 2007 Apr 20;282(16):12330-40. Epub 2007 Feb 23.


Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M.

PLoS One. 2012;7(11):e48571. doi: 10.1371/journal.pone.0048571. Epub 2012 Nov 30.


Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling.

Cowart LA, Okamoto Y, Pinto FR, Gandy JL, Almeida JS, Hannun YA.

J Biol Chem. 2003 Aug 8;278(32):30328-38. Epub 2003 May 9.


Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

Almeida T, Marques M, Mojzita D, Amorim MA, Silva RD, Almeida B, Rodrigues P, Ludovico P, Hohmann S, Moradas-Ferreira P, Côrte-Real M, Costa V.

Mol Biol Cell. 2008 Mar;19(3):865-76. Epub 2007 Dec 27.


Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis.

Wells GB, Dickson RC, Lester RL.

J Biol Chem. 1998 Mar 27;273(13):7235-43.


Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.

Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK.

Genetics. 2011 Oct;189(2):533-47. doi: 10.1534/genetics.111.132092. Epub 2011 Aug 11.


Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.

Barbosa AD, Graça J, Mendes V, Chaves SR, Amorim MA, Mendes MV, Moradas-Ferreira P, Côrte-Real M, Costa V.

Mech Ageing Dev. 2012 May;133(5):317-30. doi: 10.1016/j.mad.2012.03.007. Epub 2012 Mar 16.


The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J.

Mol Biol Cell. 2014 Jan;25(1):196-211. doi: 10.1091/mbc.E13-06-0340. Epub 2013 Nov 6.


Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.

Barbosa AD, Osório H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V.

Mol Microbiol. 2011 Jul;81(2):515-27. doi: 10.1111/j.1365-2958.2011.07714.x. Epub 2011 Jun 28.


ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae.

Kitagaki H, Cowart LA, Matmati N, Montefusco D, Gandy J, de Avalos SV, Novgorodov SA, Zheng J, Obeid LM, Hannun YA.

J Biol Chem. 2009 Apr 17;284(16):10818-30. doi: 10.1074/jbc.M805029200. Epub 2009 Jan 29.


Sphingolipids and mitochondrial function in budding yeast.

Spincemaille P, Matmati N, Hannun YA, Cammue BP, Thevissen K.

Biochim Biophys Acta. 2014 Oct;1840(10):3131-7. doi: 10.1016/j.bbagen.2014.06.015. Epub 2014 Jun 25.


Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.

Matmati N, Hannun YA.

J Lipid Res. 2008 May;49(5):922-8. doi: 10.1194/jlr.R800004-JLR200. Epub 2008 Feb 27. Review.


Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.

Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA.

J Biol Chem. 2000 Dec 15;275(50):39793-8.


Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast.

Matmati N, Metelli A, Tripathi K, Yan S, Mohanty BK, Hannun YA.

J Biol Chem. 2013 Jun 14;288(24):17272-84. doi: 10.1074/jbc.M112.444802. Epub 2013 Apr 25.


Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.

Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, Hannun YA.

J Biol Chem. 2002 Nov 8;277(45):42572-8. Epub 2002 Aug 27.

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