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Items: 1 to 20 of 229


Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.

O'Hare MJ, Kushwaha N, Zhang Y, Aleyasin H, Callaghan SM, Slack RS, Albert PR, Vincent I, Park DS.

J Neurosci. 2005 Sep 28;25(39):8954-66.


The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.

Hisanaga S, Saito T.

Neurosignals. 2003 Sep-Oct;12(4-5):221-9. Review.


Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.

Park KH, Lu G, Fan J, Raymond LA, Leavitt BR.

J Huntingtons Dis. 2012;1(1):89-96. doi: 10.3233/JHD-2012-129000.


p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons.

Saito T, Konno T, Hosokawa T, Asada A, Ishiguro K, Hisanaga S.

J Neurochem. 2007 Jul;102(1):133-40. Epub 2007 May 15.


p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death.

Lin L, Ye Y, Zakeri Z.

Cell Death Differ. 2006 Jan;13(1):141-50.


Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.

Biochem Biophys Res Commun. 2002 Nov 15;298(5):693-8.


Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH.

J Neurosci. 2003 Apr 1;23(7):2769-78.


The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.

Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, Herrup K, Zhang YW, Bu G, Xu H, Zhang J.

J Neurosci. 2015 Feb 11;35(6):2624-35. doi: 10.1523/JNEUROSCI.3051-14.2015.


The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons.

Shi LL, Yang WN, Chen XL, Zhang JS, Yang PB, Hu XD, Han H, Qian YH, Liu Y.

Neurochem Int. 2012 Jul;61(2):227-35. doi: 10.1016/j.neuint.2012.04.019. Epub 2012 Apr 25.


Increase of p25 associated with cortical neuronal death induced by hypoxia.

Huang T, Fang L, Lin Z, Huang E, Ye Q.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):932-936. doi: 10.1016/j.bbrc.2016.07.001. Epub 2016 Jul 8.


p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.

Hamdane M, Bretteville A, Sambo AV, Schindowski K, Bégard S, Delacourte A, Bertrand P, Buée L.

J Cell Sci. 2005 Mar 15;118(Pt 6):1291-8. Epub 2005 Mar 1.


Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.

Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb JA, Saido TC, Sorimachi H, Hisanaga S.

J Biol Chem. 2007 Jan 19;282(3):1687-94. Epub 2006 Nov 22.


Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153.

Zhang H, Chang L, Zhang H, Nie J, Zhang Z, Yang X, Vuong AM, Wang Z, Chen A, Niu Q.

Toxicol Lett. 2017 Aug 5;277:41-53. doi: 10.1016/j.toxlet.2017.05.027. Epub 2017 May 27.


The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.

Biochem Biophys Res Commun. 2001 Feb 2;280(4):998-1002.


Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.

Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S.

J Biol Chem. 2014 Jul 11;289(28):19627-36. doi: 10.1074/jbc.M113.501148. Epub 2014 May 28.


p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide.

Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT.

J Mol Neurosci. 2007;31(1):23-35.


p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.

Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y.

J Neurosci. 2016 Nov 2;36(44):11283-11294.


Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.

Patzke H, Tsai LH.

J Biol Chem. 2002 Mar 8;277(10):8054-60. Epub 2002 Jan 9.


Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H, Vincent I, Wang X, Mao Z, Park DS.

J Neurosci. 2006 Jan 11;26(2):440-7.


Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.

Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S.

J Neurochem. 2008 Aug;106(3):1325-36. doi: 10.1111/j.1471-4159.2008.05500.x. Epub 2008 May 26.

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