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16192383,21653898,28097492,15003856,26188960,16304633,24212047,25858491,18987162,15194687,17584831,23828908,16725114,20304940,19464796,21364461,30738091,12077606,19524560,16831854,25029033,18172555,18034335,22314297,25250537,28094445,20021572,25371244,22982061,18826653,17018028,22328719,18481914,19208258,25953616,30927254,21441412,24275229,11483711,24174527,17596195,21099148,21883144,29129206,23508958,28515697,29247491,29537196,18001466,15764707,29273526,17596456,15525269,25079903,19404626,18515644,20335377,30306512,19158342,17363391,21904821,29689522,18528787,16793902,18617618,16678970,14996838,23545271,30914247,15837819,22466126,19371406,21718307,22184123,27329106,23955021,17392405,20626063,24373353,17344381,32186131,17978048,23037317,30636360,24495935,16288992,25670203,21981454,11226681,26645885,21316356,27758864,23916509,27558883,23707800,17314320,32791143,19085565,26930003,16407761,17826200,26563747,32708653,27443158,23497345,35163843,15385613,26099309,22130664,20932251,32345612,18461159,16115206,17590514,34639197,33839411,21541689,24022869,17567713,17991581,15691846,26515068,34863944,23843517,23303863,24643480,30345869,23275609,12654248,32755305,19537933,23636721,21044960,16954222,35802479,23109716,20182791,34242501,30969886,22861649,20231274,31883821,25128576,18838811,26598901,32882205,36755306,24147119,32562269,33077140,18089839,31676602,20826794,28360106,16597917,16510717,31170994,24941663,29806907,21861907,31981911,31952468,26084409,19926130,15916949,31155288,30936039,32760273,18178674,17932142,23083124,19220220,25014183,22863862,21376466,33420359,15746091,22902197,28062485,25734989,15653710,25297838,32546738,29714412,32415171,24344247,16595689,21273322,20693293,21883148,23283344,20390747,28982207,19888597,23139219,18455988,32586044,8774434,24941668,24941664,24586504,20086034,31012378,19778904,34332978,18063314,19482068,22493457,22998799,22933780,32365623,24133266,19959819,15175387,25323897,33806052,15046718,32862473,34015320,15071115,14506258,32721035,22412190,34967443,29352512,30664549,33857022,21998141,24145133,21666106,32965166,30629470,19531269,12077604,31955004,33837959,14712238,18809334,21855605,22389490,22005042,18031925,32574651,24558480,20008466,28945920,21779403,32833423,32250774,23850608,16849427,24569998,24036102,15254097,21775597,32526735,18481133,29206105,31095448,24699274,31701438,16319926,18239961,22916273,21867704,20101408,31796207,32378567,18660449,19470296,22952227,20660715,18481913,27792844,22171045,30804201,16513770,16431906,24567510,15288402,19997638,19845671,30644819,21453681,33060203,32345727,24434067,33766560,36115537,12598622,35726573,24590823,23015437,22910182,35820471,34239123,25135718,17601667,24808184,22791718,25561742,36736078,22215506,25266715,30676422,37011502,36080196,25809255,34555418,31009639,23353045,32618816,36374622,27227029,33661801,32461255,24920628,31914619,19348834,24612851,28522561,25568328,34364049,12761211,24158445,24250792,16605259,22570472,33568699,25330307,15574747,35011580,33804707,33377418,33239401,23074220,24675661,34093200,21466812,16887920,31026506,35280525,24210884,24312564,24890824,18709364,19129393,23439120,22209625,24878626,30224169,36546250,21621010,30825343,31207668,18159132,24217926,24595220,36454632,33239169,31812705,24925072,35776390,32097697,18806809,16899456,30761248,20674858,27566753,17959807,25301522,21480900,27227014,20303522,36152181,18757526,23306082,25035428,32652086,32763303,35504659,36596769,15084474,33641357,32938721,31426314,21343315,33975636,34996439,25108402,32404326,19429642,31576531,23271050,27143360,34113239,29746471,22378825,23413875,34043299,32633621,19695100,32880575,18537644,22792028,31096838,34078339,21285946,23525210,23271453,34205555,33990108,20510930,22972391,32418082,28631948,32944976,9880573,31325598,23516290,31197115,30093524,28567799,19149636,33752082,36737562,36690845,34591198,32682914,23902373,21911503,33165872,36587734,34605028,35167888,19164517,19059884,21069423,31757360,33123873,21829089,33184836,29922176,31446830,25047038,16973931,36076974,30676872,24447516,12812762,32738201,36001079,34022223,36847817,21536874,35973467,20712533,19864432,36709668,36351417,32293931,24305161,30871017,35314195,33407019,31998070,27022021,36008373,18032651,30858408,19561608,33296594,24339305,33674682,21550252,19654265,20107070,18791833,36077412,31935455,21523557,23264033,35248760,29578059,36217603,21555515,20414199,23468922,26655809,9487017,23616546,20659296,36916676,36614317,22233379,23223305,22155782,20424317,12765693,36575892,21524089,31912230,33071817,31249525,27734949,23925292,23279936,23912940,12783886,31286024,19749171,33584270,18579526,11931994,22528458,33825665,24847275,24838827,26967694,34672430,30409787,34445178,20932253,32820172,23613529,32074545,33840685,32545311,36343259,33567446,34894399,22327653,24676478,31719194,19014578,36613861,33401283,35157132,34514518,30528162,15722340,26513481,21098484,33160235,22395410,34533076,28664062,33827400,21490957,10594048,23203269,21311684,18466747,26411767,35666427,21569553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Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

Xu H, Blair NT, Clapham DE. Xu H, et al. J Neurosci. 2005 Sep 28;25(39):8924-37. doi: 10.1523/JNEUROSCI.2574-05.2005. J Neurosci. 2005. PMID: 16192383 Free PMC article.

Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.

Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, Pimentel F, Cao DS, Evans MS, Premkumar LS. Raisinghani M, et al. Am J Physiol Cell Physiol. 2011 Sep;301(3):C587-600. doi: 10.1152/ajpcell.00465.2010. Epub 2011 Jun 8. Am J Physiol Cell Physiol. 2011. PMID: 21653898 Free PMC article.

Activation of TRPM2 and TRPV1 Channels in Dorsal Root Ganglion by NADPH Oxidase and Protein Kinase C Molecular Pathways: a Patch Clamp Study.

Nazıroğlu M. Nazıroğlu M. J Mol Neurosci. 2017 Mar;61(3):425-435. doi: 10.1007/s12031-017-0882-4. Epub 2017 Jan 17. J Mol Neurosci. 2017. PMID: 28097492

Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.

Mandadi S, Numazaki M, Tominaga M, Bhat MB, Armati PJ, Roufogalis BD. Mandadi S, et al. Cell Calcium. 2004 May;35(5):471-8. doi: 10.1016/j.ceca.2003.11.003. Cell Calcium. 2004. PMID: 15003856

Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.

Iwaoka E, Wang S, Matsuyoshi N, Kogure Y, Aoki S, Yamamoto S, Noguchi K, Dai Y. Iwaoka E, et al. J Nat Med. 2016 Jan;70(1):1-7. doi: 10.1007/s11418-015-0929-1. Epub 2015 Jul 19. J Nat Med. 2016. PMID: 26188960 Free PMC article.

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.

Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, Noguchi K. Kobayashi K, et al. J Comp Neurol. 2005 Dec 26;493(4):596-606. doi: 10.1002/cne.20794. J Comp Neurol. 2005. PMID: 16304633

Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons.

Zhang X, Koronowski KB, Li L, Freeman BA, Woodcock S, de Groat WC. Zhang X, et al. Exp Neurol. 2014 Jan;251:12-21. doi: 10.1016/j.expneurol.2013.10.020. Epub 2013 Nov 8. Exp Neurol. 2014. PMID: 24212047 Free PMC article.

Role of calcium ions in the positive interaction between TRPA1 and TRPV1 channels in bronchopulmonary sensory neurons.

Hsu CC, Lee LY. Hsu CC, et al. J Appl Physiol (1985). 2015 Jun 15;118(12):1533-43. doi: 10.1152/japplphysiol.00043.2015. Epub 2015 Apr 9. J Appl Physiol (1985). 2015. PMID: 25858491 Free PMC article.

Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate.

Ohta T, Imagawa T, Ito S. Ohta T, et al. Mol Pharmacol. 2009 Feb;75(2):307-17. doi: 10.1124/mol.108.051292. Epub 2008 Nov 5. Mol Pharmacol. 2009. PMID: 18987162

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.

Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX. Hu HZ, et al. J Biol Chem. 2004 Aug 20;279(34):35741-8. doi: 10.1074/jbc.M404164200. Epub 2004 Jun 11. J Biol Chem. 2004. PMID: 15194687 Free article.

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