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Items: 1 to 20 of 80

1.

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.

Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J.

Blood. 2006 Jan 1;107(1):176-83. Epub 2005 Sep 20.

2.

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Williams NK, Bamert RS, Patel O, Wang C, Walden PM, Wilks AF, Fantino E, Rossjohn J, Lucet IS.

J Mol Biol. 2009 Mar 20;387(1):219-32. doi: 10.1016/j.jmb.2009.01.041. Epub 2009 Jan 29.

PMID:
19361440
3.

Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.

Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, Renwick SB, Tanner AJ, Frantz JD, Fleming MA, Cheetham GM.

J Biol Chem. 2004 Apr 30;279(18):18727-32. Epub 2004 Feb 6.

4.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z.

J Biol Chem. 2015 Nov 6;290(45):27261-70. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10.

5.
6.

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

Chrencik JE, Patny A, Leung IK, Korniski B, Emmons TL, Hall T, Weinberg RA, Gormley JA, Williams JM, Day JE, Hirsch JL, Kiefer JR, Leone JW, Fischer HD, Sommers CD, Huang HC, Jacobsen EJ, Tenbrink RE, Tomasselli AG, Benson TE.

J Mol Biol. 2010 Jul 16;400(3):413-33. doi: 10.1016/j.jmb.2010.05.020. Epub 2010 May 15.

PMID:
20478313
7.

A novel function for a glucose analog of blood group H antigen as a mediator of leukocyte-endothelial adhesion via intracellular adhesion molecule 1.

Zhu K, Amin MA, Kim MJ, Katschke KJ Jr, Park CC, Koch AE.

J Biol Chem. 2003 Jun 13;278(24):21869-77. Epub 2003 Apr 2.

8.

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.

Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T.

Mol Cell Biol. 1996 Dec;16(12):6985-92.

9.

Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.

Dalgarno D, Stehle T, Narula S, Schelling P, van Schravendijk MR, Adams S, Andrade L, Keats J, Ram M, Jin L, Grossman T, MacNeil I, Metcalf C 3rd, Shakespeare W, Wang Y, Keenan T, Sundaramoorthi R, Bohacek R, Weigele M, Sawyer T.

Chem Biol Drug Des. 2006 Jan;67(1):46-57.

PMID:
16492148
10.

Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.

McInnes C, Wang S, Anderson S, O'Boyle J, Jackson W, Kontopidis G, Meades C, Mezna M, Thomas M, Wood G, Lane DP, Fischer PM.

Chem Biol. 2004 Apr;11(4):525-34.

11.

Determination of the transphosphorylation sites of Jak2 kinase.

Matsuda T, Feng J, Witthuhn BA, Sekine Y, Ihle JN.

Biochem Biophys Res Commun. 2004 Dec 10;325(2):586-94.

PMID:
15530433
12.

A functional Jak2 tyrosine kinase domain is essential for mouse development.

Frenzel K, Wallace TA, McDoom I, Xiao HD, Capecchi MR, Bernstein KE, Sayeski PP.

Exp Cell Res. 2006 Sep 10;312(15):2735-44. Epub 2006 May 16.

PMID:
16887119
14.

Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages.

Okugawa S, Ota Y, Kitazawa T, Nakayama K, Yanagimoto S, Tsukada K, Kawada M, Kimura S.

Am J Physiol Cell Physiol. 2003 Aug;285(2):C399-408. Epub 2003 Apr 9.

15.
16.

Structural basis for selective inhibition of Src family kinases by PP1.

Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM.

Chem Biol. 1999 Sep;6(9):671-8.

17.

Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490.

Rashid S, Bibi N, Parveen Z, Shafique S.

J Biomol Struct Dyn. 2015;33(11):2368-79. doi: 10.1080/07391102.2015.1050696. Epub 2015 Jun 23.

PMID:
26017266
18.

Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.

Dymock BW, See CS.

Expert Opin Ther Pat. 2013 Apr;23(4):449-501. doi: 10.1517/13543776.2013.765862. Epub 2013 Feb 1. Review.

PMID:
23367873
19.

The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.

Jin L, Pluskey S, Petrella EC, Cantin SM, Gorga JC, Rynkiewicz MJ, Pandey P, Strickler JE, Babine RE, Weaver DT, Seidl KJ.

J Biol Chem. 2004 Oct 8;279(41):42818-25. Epub 2004 Jul 29.

20.

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