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Items: 1 to 20 of 144


Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.


Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.

Lee JN, Song B, DeBose-Boyd RA, Ye J.

J Biol Chem. 2006 Dec 22;281(51):39308-15. Epub 2006 Oct 16.


Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.

Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL.

Cell Metab. 2007 Aug;6(2):115-28.


Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.

Mol Biol Cell. 2012 Dec;23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19.


Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Jo Y, Sguigna PV, DeBose-Boyd RA.

J Biol Chem. 2011 Apr 29;286(17):15022-31. doi: 10.1074/jbc.M110.211326. Epub 2011 Feb 22.


Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo Y, Debose-Boyd RA.

Crit Rev Biochem Mol Biol. 2010 Jun;45(3):185-98. doi: 10.3109/10409238.2010.485605. Review.


Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells.

Elsabrouty R, Jo Y, Dinh TT, DeBose-Boyd RA.

Mol Biol Cell. 2013 Nov;24(21):3300-8. doi: 10.1091/mbc.E13-03-0157. Epub 2013 Sep 11.


Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen AD, Lee SH, DeBose-Boyd RA.

J Biol Chem. 2009 Sep 25;284(39):26778-88. doi: 10.1074/jbc.M109.032342. Epub 2009 Jul 28.


Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.

Faulkner RA, Nguyen AD, Jo Y, DeBose-Boyd RA.

J Lipid Res. 2013 Apr;54(4):1011-22. doi: 10.1194/jlr.M033639. Epub 2013 Feb 12.


Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA.

J Biol Chem. 2003 Dec 26;278(52):52479-90. Epub 2003 Oct 16.


Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation.

Lee PC, Nguyen AD, Debose-Boyd RA.

J Lipid Res. 2007 Feb;48(2):318-27. Epub 2006 Nov 7.


Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA.

Mol Cell. 2003 Jan;11(1):25-33.


Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

Lee PC, Sever N, Debose-Boyd RA.

J Biol Chem. 2005 Jul 1;280(26):25242-9. Epub 2005 May 2.


Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.

Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S.

J Biol Chem. 2007 Nov 23;282(47):33908-14. Epub 2007 Sep 14.


Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Leichner GS, Avner R, Harats D, Roitelman J.

Mol Biol Cell. 2009 Jul;20(14):3330-41. doi: 10.1091/mbc.E08-09-0953. Epub 2009 May 20.

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