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Items: 1 to 20 of 76

1.
2.

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA.

Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C.

Nature. 2005 Sep 15;437(7057):440-3.

PMID:
16163361
3.

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.

PMID:
17713585
5.

MRE11/RAD50/NBS1: complex activities.

Assenmacher N, Hopfner KP.

Chromosoma. 2004 Oct;113(4):157-66. Epub 2004 Aug 10. Review.

PMID:
15309560
6.

The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.

Lee AY, Liu E, Wu X.

J Biol Chem. 2007 Nov 2;282(44):32243-55. Epub 2007 Aug 22.

7.

DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci.

Robison JG, Lu L, Dixon K, Bissler JJ.

J Biol Chem. 2005 Apr 1;280(13):12927-34. Epub 2005 Jan 14.

8.

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.

Hari FJ, Spycher C, Jungmichel S, Pavic L, Stucki M.

EMBO Rep. 2010 May;11(5):387-92. doi: 10.1038/embor.2010.30. Epub 2010 Mar 12.

9.

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.

Dzikiewicz-Krawczyk A.

Mutat Res. 2008 Sep-Oct;659(3):262-73. doi: 10.1016/j.mrrev.2008.05.005. Epub 2008 Jun 23. Review.

PMID:
18606567
10.

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M.

J Cell Biol. 2008 Apr 21;181(2):227-40. doi: 10.1083/jcb.200709008. Epub 2008 Apr 14.

11.

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.

Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC.

Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2024-32.

12.

MRN and the race to the break.

Rupnik A, Lowndes NF, Grenon M.

Chromosoma. 2010 Apr;119(2):115-35. doi: 10.1007/s00412-009-0242-4. Epub 2009 Oct 28. Review.

PMID:
19862546
13.

Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.

Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR.

J Biol Chem. 2007 Oct 5;282(40):29314-22. Epub 2007 Aug 9.

14.

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

Lafrance-Vanasse J, Williams GJ, Tainer JA.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):182-93. doi: 10.1016/j.pbiomolbio.2014.12.004. Epub 2015 Jan 7. Review.

16.

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

Chen L, Nievera CJ, Lee AY, Wu X.

J Biol Chem. 2008 Mar 21;283(12):7713-20. doi: 10.1074/jbc.M710245200. Epub 2008 Jan 2.

17.

MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.

Roques C, Coulombe Y, Delannoy M, Vignard J, Grossi S, Brodeur I, Rodrigue A, Gautier J, Stasiak AZ, Stasiak A, Constantinou A, Masson JY.

EMBO J. 2009 Aug 19;28(16):2400-13. doi: 10.1038/emboj.2009.193. Epub 2009 Jul 16.

18.

DNA double-strand breaks come into focus.

Hopfner KP.

Cell. 2009 Oct 2;139(1):25-7. doi: 10.1016/j.cell.2009.09.017.

19.

The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes.

Paull TT, Deshpande RA.

Exp Cell Res. 2014 Nov 15;329(1):139-47. doi: 10.1016/j.yexcr.2014.07.007. Epub 2014 Jul 9. Review. No abstract available.

20.

Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.

Kavitha CV, Choudhary B, Raghavan SC, Muniyappa K.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):575-80. doi: 10.1016/j.bbrc.2010.07.117. Epub 2010 Aug 2.

PMID:
20682289

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