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Items: 1 to 20 of 173

1.

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

Hass MR, Yankner BA.

J Biol Chem. 2005 Nov 4;280(44):36895-904. Epub 2005 Aug 15.

2.

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

Cao X, Südhof TC.

J Biol Chem. 2004 Jun 4;279(23):24601-11. Epub 2004 Mar 24.

3.

Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction.

Kim SY, Kim MY, Mo JS, Park HS.

Biochim Biophys Acta. 2007 Jun;1773(6):736-46. Epub 2007 Feb 14.

4.

Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.

Riese F, Grinschgl S, Gersbacher MT, Russi N, Hock C, Nitsch RM, Konietzko U.

PLoS One. 2013 Sep 25;8(9):e76094. doi: 10.1371/journal.pone.0076094. eCollection 2013.

5.

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.

Kinoshita A, Whelan CM, Berezovska O, Hyman BT.

J Biol Chem. 2002 Aug 9;277(32):28530-6. Epub 2002 May 24.

6.

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

Cao X, Südhof TC.

Science. 2001 Jul 6;293(5527):115-20. Erratum in: Science 2001 Aug 24;293(5534):1436.

7.

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.

Konietzko U, Goodger ZV, Meyer M, Kohli BM, Bosset J, Lahiri DK, Nitsch RM.

Neurobiol Aging. 2010 Jan;31(1):58-73. doi: 10.1016/j.neurobiolaging.2008.03.001. Epub 2008 Apr 10.

8.

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.

von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U.

J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48.

10.

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ.

Biochemistry. 2003 Jun 10;42(22):6664-73.

PMID:
12779321
12.

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.

Li Q, Südhof TC.

J Biol Chem. 2004 Mar 12;279(11):10542-50. Epub 2003 Dec 29.

13.

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.

Scheinfeld MH, Ghersi E, Laky K, Fowlkes BJ, D'Adamio L.

J Biol Chem. 2002 Nov 15;277(46):44195-201. Epub 2002 Sep 12.

14.

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7.

15.

Turnover of amyloid precursor protein family members determines their nuclear signaling capability.

Gersbacher MT, Goodger ZV, Trutzel A, Bundschuh D, Nitsch RM, Konietzko U.

PLoS One. 2013 Jul 18;8(7):e69363. doi: 10.1371/journal.pone.0069363. Print 2013.

16.

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.

J Neurochem. 2000 Aug;75(2):583-93.

17.

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.

Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ.

J Biol Chem. 2001 Oct 26;276(43):40288-92. Epub 2001 Sep 5.

19.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

20.

A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.

Słomnicki LP, Leśniak W.

Acta Neurobiol Exp (Wars). 2008;68(2):219-28. Review.

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