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Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).

Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL.

J Agric Food Chem. 2005 Aug 10;53(16):6246-53.


The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.

Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR.

J Altern Complement Med. 2006 Mar;12(2):133-9.


Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.

J Agric Food Chem. 2001 May;49(5):2472-9.


In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.

Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.

Chem Biol Interact. 2008 Oct 22;176(1):30-9. doi: 10.1016/j.cbi.2008.06.005. Epub 2008 Jun 20.


Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.

Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL.

PLoS One. 2013 Jul 12;8(7):e67947. doi: 10.1371/journal.pone.0067947. Print 2013.


Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.

Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR.

J Agric Food Chem. 2006 Feb 22;54(4):1277-82.


Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: an in vitro study in MCF-7 cells.

Spagnuolo P, Rasini E, Luini A, Legnaro M, Luzzani M, Casareto E, Carreri M, Paracchini S, Marino F, Cosentino M.

Fitoterapia. 2014 Apr;94:62-9. doi: 10.1016/j.fitote.2014.01.027. Epub 2014 Feb 5.


Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.

Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A.

J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):259-68.


Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.

Effenberger KE, Johnsen SA, Monroe DG, Spelsberg TC, Westendorf JJ.

J Steroid Biochem Mol Biol. 2005 Sep;96(5):387-99. Epub 2005 Jul 12.


Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.

Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB.

Biomed Chromatogr. 2014 Jun;28(6):729-34. doi: 10.1002/bmc.3177.


Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation.

Wang S, Dunlap TL, Howell CE, Mbachu OC, Rue EA, Phansalkar R, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2016 Jul 18;29(7):1142-50. doi: 10.1021/acs.chemrestox.6b00112. Epub 2016 Jun 22.


Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.

van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen SN, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikolic D.

Mol Nutr Food Res. 2014 Oct;58(10):1962-9. doi: 10.1002/mnfr.201400245. Epub 2014 Sep 16.


The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties.

Chadwick LR, Pauli GF, Farnsworth NR.

Phytomedicine. 2006 Jan;13(1-2):119-31. Epub 2005 Jul 1. Review.


The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover.

Lutter S, Schmalbach K, Esch HL, Lehmann L.

Arch Toxicol. 2014 Feb;88(2):309-21. doi: 10.1007/s00204-013-1114-5. Epub 2013 Aug 28.


High-content screening and mechanism-based evaluation of estrogenic botanical extracts.

Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL.

Comb Chem High Throughput Screen. 2008 May;11(4):283-93.


Influence of red clover (Trifolium pratense) isoflavones on gene and protein expression profiles in liver of ovariectomized rats.

Pakalapati G, Li L, Gretz N, Koch E, Wink M.

Phytomedicine. 2009 Sep;16(9):845-55. doi: 10.1016/j.phymed.2009.03.003. Epub 2009 May 5.


Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).

Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL.

Cancer Prev Res (Phila). 2012 Jan;5(1):73-81. doi: 10.1158/1940-6207.CAPR-11-0348. Epub 2011 Oct 13.


Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?

Beck V, Rohr U, Jungbauer A.

J Steroid Biochem Mol Biol. 2005 Apr;94(5):499-518. Epub 2005 Mar 23. Review.


DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.

Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF.

J Nat Prod. 2017 Aug 25;80(8):2284-2294. doi: 10.1021/acs.jnatprod.7b00284. Epub 2017 Aug 16.

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