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Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.

Chubanov V, Gudermann T, Schlingmann KP.

Pflugers Arch. 2005 Oct;451(1):228-34. Epub 2005 Jun 17. Review.


TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism.

Schlingmann KP, Waldegger S, Konrad M, Chubanov V, Gudermann T.

Biochim Biophys Acta. 2007 Aug;1772(8):813-21. Epub 2007 Apr 3. Review.


A critical role of TRPM channel-kinase for human magnesium transport.

Schlingmann KP, Gudermann T.

J Physiol. 2005 Jul 15;566(Pt 2):301-8. Epub 2005 Apr 21. Review.


Insights into the molecular nature of magnesium homeostasis.

Konrad M, Schlingmann KP, Gudermann T.

Am J Physiol Renal Physiol. 2004 Apr;286(4):F599-605. Review.


Recent developments in intestinal magnesium absorption.

Quamme GA.

Curr Opin Gastroenterol. 2008 Mar;24(2):230-5. doi: 10.1097/MOG.0b013e3282f37b59.


Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.

Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M.

Nat Genet. 2002 Jun;31(2):166-70. Epub 2002 May 28.


TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.

Brandao K, Deason-Towne F, Zhao X, Perraud AL, Schmitz C.

Cell Mol Life Sci. 2014 Dec;71(24):4853-67. doi: 10.1007/s00018-014-1647-7. Epub 2014 May 25.


TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.

Voets T, Nilius B, Hoefs S, van der Kemp AW, Droogmans G, Bindels RJ, Hoenderop JG.

J Biol Chem. 2004 Jan 2;279(1):19-25. Epub 2003 Oct 23.


Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.

Touyz RM.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1103-18. doi: 10.1152/ajpheart.00903.2007. Epub 2008 Jan 11. Review.


Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR.

Biochem J. 2014 Jun 1;460(2):165-75. doi: 10.1042/BJ20131639.


Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

Chubanov V, Waldegger S, Mederos y Schnitzler M, Vitzthum H, Sassen MC, Seyberth HW, Konrad M, Gudermann T.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2894-9. Epub 2004 Feb 19.


Molecular components of vertebrate Mg2+-homeostasis regulation.

Schmitz C, Deason F, Perraud AL.

Magnes Res. 2007 Mar;20(1):6-18. Review.


Insight into the molecular regulation of the epithelial magnesium channel TRPM6.

Cao G, Hoenderop JG, Bindels RJ.

Curr Opin Nephrol Hypertens. 2008 Jul;17(4):373-8. doi: 10.1097/MNH.0b013e328303e184. Review.


The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens.

Groenestege WM, Hoenderop JG, van den Heuvel L, Knoers N, Bindels RJ.

J Am Soc Nephrol. 2006 Apr;17(4):1035-43. Epub 2006 Mar 8.


New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.

Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG.

Eur J Hum Genet. 2014 Apr;22(4):497-504. doi: 10.1038/ejhg.2013.178. Epub 2013 Aug 14.


[TRPM7: a protein responsible for magnesium homeostasis in a cell].

Trzeciakiewicz A, Opolski A, Mazur A.

Postepy Hig Med Dosw (Online). 2005;59:496-502. Review. Polish.


The channel kinases TRPM6 and TRPM7 are functionally nonredundant.

Schmitz C, Dorovkov MV, Zhao X, Davenport BJ, Ryazanov AG, Perraud AL.

J Biol Chem. 2005 Nov 11;280(45):37763-71. Epub 2005 Sep 2.


Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6.

Chubanov V, Schlingmann KP, Wäring J, Heinzinger J, Kaske S, Waldegger S, Mederos y Schnitzler M, Gudermann T.

J Biol Chem. 2007 Mar 9;282(10):7656-67. Epub 2006 Dec 29.


The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A.

J Biol Chem. 2014 Feb 21;289(8):5217-27. doi: 10.1074/jbc.M113.512285. Epub 2014 Jan 2.

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