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Items: 1 to 20 of 161


Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.

Yuan YR, Pei Y, Ma JB, Kuryavyi V, Zhadina M, Meister G, Chen HY, Dauter Z, Tuschl T, Patel DJ.

Mol Cell. 2005 Aug 5;19(3):405-19.


Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.

Ma JB, Yuan YR, Meister G, Pei Y, Tuschl T, Patel DJ.

Nature. 2005 Mar 31;434(7033):666-70.


Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.

Rashid UJ, Paterok D, Koglin A, Gohlke H, Piehler J, Chen JC.

J Biol Chem. 2007 May 4;282(18):13824-32. Epub 2006 Nov 27.


Molecular biology. Argonaute journeys into the heart of RISC.

Sontheimer EJ, Carthew RW.

Science. 2004 Sep 3;305(5689):1409-10. No abstract available.


Crystal structure of Argonaute and its implications for RISC slicer activity.

Song JJ, Smith SK, Hannon GJ, Joshua-Tor L.

Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29.


Characterization of RNase HII substrate recognition using RNase HII-argonaute chimaeric enzymes from Pyrococcus furiosus.

Kitamura S, Fujishima K, Sato A, Tsuchiya D, Tomita M, Kanai A.

Biochem J. 2010 Feb 24;426(3):337-44. doi: 10.1042/BJ20091553.


Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.

Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, Patel DJ.

Nature. 2009 Oct 8;461(7265):754-61. doi: 10.1038/nature08434.


Structure of the guide-strand-containing argonaute silencing complex.

Wang Y, Sheng G, Juranek S, Tuschl T, Patel DJ.

Nature. 2008 Nov 13;456(7219):209-13. doi: 10.1038/nature07315. Epub 2008 Aug 27.


Purified Argonaute2 and an siRNA form recombinant human RISC.

Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L.

Nat Struct Mol Biol. 2005 Apr;12(4):340-9. Epub 2005 Mar 30.


C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.

Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q.

Science. 2009 Aug 7;325(5941):750-3. doi: 10.1126/science.1176325.


Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity.

Parker JS, Roe SM, Barford D.

EMBO J. 2004 Dec 8;23(24):4727-37. Epub 2004 Nov 25.


Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.

Blaszczyk J, Tropea JE, Bubunenko M, Routzahn KM, Waugh DS, Court DL, Ji X.

Structure. 2001 Dec;9(12):1225-36.


PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA.

Musiyenko A, Majumdar T, Andrews J, Adams B, Barik S.

Cell Microbiol. 2012 Jun;14(6):882-901. doi: 10.1111/j.1462-5822.2012.01763.x. Epub 2012 Feb 28.


The role of PACT in the RNA silencing pathway.

Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN.

EMBO J. 2006 Feb 8;25(3):522-32. Epub 2006 Jan 19.


Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M.

Nucleic Acids Res. 2007;35(19):6424-38. Epub 2007 Sep 18.


Structure of C3PO and mechanism of human RISC activation.

Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H.

Nat Struct Mol Biol. 2011 Jun;18(6):650-7. doi: 10.1038/nsmb.2032. Epub 2011 May 8.


The N domain of Argonaute drives duplex unwinding during RISC assembly.

Kwak PB, Tomari Y.

Nat Struct Mol Biol. 2012 Jan 10;19(2):145-51. doi: 10.1038/nsmb.2232.


Argonaute2 is the catalytic engine of mammalian RNAi.

Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ.

Science. 2004 Sep 3;305(5689):1437-41. Epub 2004 Jul 29.


Eukaryote-specific insertion elements control human ARGONAUTE slicer activity.

Nakanishi K, Ascano M, Gogakos T, Ishibe-Murakami S, Serganov AA, Briskin D, Morozov P, Tuschl T, Patel DJ.

Cell Rep. 2013 Jun 27;3(6):1893-900. doi: 10.1016/j.celrep.2013.06.010.

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