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Items: 1 to 20 of 186

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Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

Lee PC, Sever N, Debose-Boyd RA.

J Biol Chem. 2005 Jul 1;280(26):25242-9. Epub 2005 May 2.

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Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Leichner GS, Avner R, Harats D, Roitelman J.

Mol Biol Cell. 2009 Jul;20(14):3330-41. doi: 10.1091/mbc.E08-09-0953. Epub 2009 May 20.

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Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.

Trzaskos JM, Magolda RL, Favata MF, Fischer RT, Johnson PR, Chen HW, Ko SS, Leonard DA, Gaylor JL.

J Biol Chem. 1993 Oct 25;268(30):22591-9.

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Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation.

Lee PC, Nguyen AD, Debose-Boyd RA.

J Lipid Res. 2007 Feb;48(2):318-27. Epub 2006 Nov 7.

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Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

Lee PC, DeBose-Boyd RA.

J Lipid Res. 2010 Jan;51(1):192-201. doi: 10.1194/jlr.M900336-JLR200.

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Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA.

J Biol Chem. 2003 Dec 26;278(52):52479-90. Epub 2003 Oct 16.

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA.

Mol Cell. 2003 Jan;11(1):25-33.

16.

Insulin-induced gene: a new regulator in lipid metabolism.

Dong XY, Tang SQ.

Peptides. 2010 Nov;31(11):2145-50. doi: 10.1016/j.peptides.2010.07.020. Epub 2010 Sep 15. Review.

PMID:
20817058
17.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.

18.

Dual functions of Insig proteins in cholesterol homeostasis.

Dong XY, Tang SQ, Chen JD.

Lipids Health Dis. 2012 Dec 18;11:173. doi: 10.1186/1476-511X-11-173. Review.

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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols.

Panini SR, Sexton RC, Gupta AK, Parish EJ, Chitrakorn S, Rudney H.

J Lipid Res. 1986 Nov;27(11):1190-204.

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