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Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS.

Cell Metab. 2005 Jan;1(1):41-51.


SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I.

Genes Dev. 2001 May 15;15(10):1206-16.


Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

Korn BS, Shimomura I, Bashmakov Y, Hammer RE, Horton JD, Goldstein JL, Brown MS.

J Clin Invest. 1998 Dec 15;102(12):2050-60.


The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity.

Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Müller M, Kersten S.

J Biol Chem. 2006 Jan 13;281(2):934-44. Epub 2005 Nov 4. Erratum in: J Biol Chem. 2006 Jul 28;281(30):21575.


Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G.

J Clin Invest. 2004 Apr;113(8):1168-75.


Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE.

J Biol Chem. 2003 Sep 19;278(38):36652-60. Epub 2003 Jul 10.


PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.

Nat Commun. 2015 Aug 27;6:8100. doi: 10.1038/ncomms9100.


Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS.

Cell Metab. 2005 Feb;1(2):107-19.


Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis.

Wagner EM, Kratky D, Haemmerle G, Hrzenjak A, Kostner GM, Steyrer E, Zechner R.

J Lipid Res. 2004 Feb;45(2):356-65. Epub 2003 Nov 1.


Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.

Liu LF, Purushotham A, Wendel AA, Belury MA.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. Epub 2007 Feb 22.


Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice.

Lee MS, Kim CT, Kim Y.

Ann Nutr Metab. 2009;54(2):151-7. doi: 10.1159/000214834. Epub 2009 Apr 22.


Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease.

Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR.

Eur J Gastroenterol Hepatol. 2008 Sep;20(9):843-54. doi: 10.1097/MEG.0b013e3282f9b203.


Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.

Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32. Epub 2003 Sep 25.


Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity.

Wang Y, Iordanov H, Swietlicki EA, Wang L, Fritsch C, Coleman T, Semenkovich CF, Levin MS, Rubin DC.

J Biol Chem. 2005 Oct 14;280(41):34764-75. Epub 2005 Aug 5.


Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs.

Luci S, Giemsa B, Kluge H, Eder K.

Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R70-7. Epub 2007 Mar 15.


Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.

Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R.

Obesity (Silver Spring). 2010 Apr;18(4):780-7. doi: 10.1038/oby.2009.301. Epub 2009 Oct 1.


The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.

Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD.

Cell Metab. 2012 Feb 8;15(2):240-6. doi: 10.1016/j.cmet.2011.12.017.


Plasma oestrone-fatty acid ester levels are correlated with body fat mass in humans.

Fernández-Real JM, Sanchis D, Ricart W, Casamitjana R, Balada F, Remesar X, Alemany M.

Clin Endocrinol (Oxf). 1999 Feb;50(2):253-60.


Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.

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