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Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons.

Liu T, Khanna KM, Carriere BN, Hendricks RL.

J Virol. 2001 Nov;75(22):11178-84.


The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta.

Härle P, Sainz B Jr, Carr DJ, Halford WP.

Virology. 2002 Feb 15;293(2):295-304.


Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia.

Pan D, Pesola JM, Li G, McCarron S, Coen DM.

J Virol. 2017 Jan 3;91(2). pii: e02001-16. doi: 10.1128/JVI.02001-16. Print 2017 Jan 15.


Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System.

Li L, Li Z, Wang E, Yang R, Xiao Y, Han H, Lang F, Li X, Xia Y, Gao F, Li Q, Fraser NW, Zhou J.

J Virol. 2015 Oct 28;90(2):790-804. doi: 10.1128/JVI.02258-15. Print 2016 Jan 15.


Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2.

Jiang X, Brown D, Osorio N, Hsiang C, BenMohamed L, Wechsler SL.

J Neurovirol. 2016 Feb;22(1):38-49. doi: 10.1007/s13365-015-0362-y. Epub 2015 Jun 12.


Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts.

Maillet S, Naas T, Crepin S, Roque-Afonso AM, Lafay F, Efstathiou S, Labetoulle M.

J Virol. 2006 Sep;80(18):9310-21.


Replication, establishment of latent infection, expression of the latency-associated transcripts and explant reactivation of herpes simplex virus type 1 gamma 34.5 mutants in a mouse eye model.

Spivack JG, Fareed MU, Valyi-Nagy T, Nash TC, O'Keefe JS, Gesser RM, McKie EA, MacLean AR, Fraser NW, Brown SM.

J Gen Virol. 1995 Feb;76 ( Pt 2):321-32.


CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons.

Liu T, Khanna KM, Chen X, Fink DJ, Hendricks RL.

J Exp Med. 2000 May 1;191(9):1459-66.


Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation.

Cherpes TL, Busch JL, Sheridan BS, Harvey SA, Hendricks RL.

J Immunol. 2008 Jul 15;181(2):969-75.


Delaying the expression of herpes simplex virus type 1 glycoprotein B (gB) to a true late gene alters neurovirulence and inhibits the gB-CD8+ T-cell response in the trigeminal ganglion.

Ramachandran S, Davoli KA, Yee MB, Hendricks RL, Kinchington PR.

J Virol. 2010 Sep;84(17):8811-20. doi: 10.1128/JVI.00496-10. Epub 2010 Jun 23.

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