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Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.


Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS.

Diabetes. 1998 Mar;47(3):358-64.


Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.

Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI.

Diabetes. 1997 Sep;46(9):1434-9.


Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. doi: 10.1152/ajpendo.00569.2007. Epub 2008 Jan 29.


Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

Dickson LM, Rhodes CJ.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E192-8. Review.


Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains.

Jones HB, Nugent D, Jenkins R.

Int J Exp Pathol. 2010 Jun;91(3):288-301. doi: 10.1111/j.1365-2613.2010.00713.x. Epub 2010 Apr 1.


Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.

Zhou YP, Cockburn BN, Pugh W, Polonsky KS.

Metabolism. 1999 Jul;48(7):857-64.


Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals.

Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C.

Circ Res. 2005 Sep 30;97(7):725-33. Epub 2005 Aug 25.


Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.

Rafacho A, Ribeiro DL, Boschero AC, Taboga SR, Bosqueiro JR.

Int J Exp Pathol. 2008 Aug;89(4):264-75. doi: 10.1111/j.1365-2613.2008.00588.x. Epub 2008 Apr 21.


Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. doi: 10.1007/s00125-009-1317-8. Epub 2009 Mar 18.


Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.

Ogino T, Zhu M, Murakami T, Kuwajima M, Shima K.

J Med Invest. 1998 Aug;45(1-4):103-10.


Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats.

Tse EO, Gregoire FM, Reusens B, Remacle C, Hoet JJ, Johnson PR, Stern JS.

Obes Res. 1997 Nov;5(6):563-71.


Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.

Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE.

Diabetes. 2001 May;50(5):1021-9.


Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.


Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects.

De Vita G, Berlingieri MT, Visconti R, Castellone MD, Viglietto G, Baldassarre G, Zannini M, Bellacosa A, Tsichlis PN, Fusco A, Santoro M.

Cancer Res. 2000 Jul 15;60(14):3916-20.


Hydrolysed casein diet protects BB rats from developing diabetes by promoting islet neogenesis.

Wang GS, Gruber H, Smyth P, Pulido O, Rosenberg L, Duguid W, Scott FW.

J Autoimmun. 2000 Dec;15(4):407-16.


Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.

Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG.

J Clin Invest. 2003 Jul;112(2):197-208. Epub 2003 Jul 3.

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