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16039863,8691474,14584957,10395486,16279780,9719595,9554874,9301666,14998335,9548816,9804692,16971132,14604679,9089339,15214795,15267250,19748785,18467105,9191971,12699390,9301665,29691154,7562910,27894589,10090784,15615538,9046331,8627607,9357537,9526565,16990006,9703473,11052789,8230134,19286381,11960504,22734697,15322256,18557606,9397172,20056546,12773035,8632434,23900004,16735117,31200235,18367480,28152430,28258797,10956221,20580561,23770449,10346932,16078850,15837298,9857098,18381963,16494969,17552508,30098869,20036565,17269758,19415663,9046338,31260878,20092323,12877583,8795269,21724404,16000000,28711701,20219270,16451071,15974594,16033269,20350811,9240345,15771433,22223377,15743179,17672445,9784112,18214841,11384244,20363634,16162008,15571870,19111461,19719239,15943473,9022795,16483772,18605720,8164259,20696582,8627606,19854051,17010625,11754594,23362959,18800768,12855656,16480284,18555562,20403693,27886545,20558072,10411487,25882519,24090920,19010843,18324761,19028425,18508264,9046337,11597474,14640546,15115391,18809244,17539622,17975007,21028894,16181688,17276055,10229634,15615522,15715478,17184594,23375090,26057816,23792351,18163551,16923349,36270170,16891463,15026078,15210154,17085673,22739090,19039816,15743188,18362070,9627670,19874136,14971308,19939682,24531230,17569517,18324759,18161903,7752201,8632413,22372864,17532099,19857963,12467708,11962509,15837294,10993224,10766294,14987824,17092728,18056255,15242247,22695126,21664013,10335266,18536013,21429632,12916055,15142554,16458503,19301902,18500794,8960561,12570380,7783147,19769933,16949284,26318056,22277588,18072727,26994844,10579848,20493747,21443205,28865294,20452776,20005116,8230096,15027847,2016722,12825933,20570526,12198294,20045222,22811999,20850310,22269278,29691153,9294866,25792141,21755528,24890652,20379969,19879023,15113582,20138760,25668494,20056425,19894727,22204741,12467717,20356655,30624926,15615544,20006929,12244486,20850308,14741022,24565969,12408727,20211564,20970221,9109647,23552564,20604799,24456902,8627598,20471842,19652333,20580136,21879757,19879134,21568878,15771417,26979156,14711307,22559926,21852129,10638483,36382444,27397497,23454532,20045716,14695838,12925791,22182581,11563044,22703705,19371039,15288254,2810335,21602147,20456972,21632243,7728932,21353546,21495671,15109643,25139568,20493716,27080011,16033277,26317331,21665484,15582458,11426641,31463965,22018877,34329992,15139760,29547832,21550809,22056277,22361272,22424148,15911313,23715382,8663912,22575050,14678955,19914837,33187806,23851116,20509775,15360213,21146812,15015598,28499189,21684737,21920766,29864684,9719607,23644219,10766297,15313924,3237569,12683746,22707438,21384418,20304537,24894557,10893303,15299851,36257809,18066886,3503990,15015595,7155133,8691451,15163181,12210778,7629801,24135459,15081029,25084146,19084416,12096917,7553969,7972309,22414612,8201595,20952196,15727881,31813475,23923540,28177228,15857949,27557134,19896845,20873740,14604396,28552339,32752079,23059545,26712094,27017552,23157590,20488588,15039552,24119291,21450375,21986587,27155464,21146434,15999992,22560627,19875283,36430425,11709300,17005826,21705114,9448705,20183608,23811090,23124213,22263917,27477657,9523991,15109642,22533316,15670934,9816221,14640561,19853327,20085328,15893928,22483592,26575787,15718161,20403700,18680275,28403784,15317473,21302360,14682686,301777,29453377,21823617,20833039,29448140,10466054,22229669,21623630,20728460,20192239,27875779,26134001,23627352,21123866,9540108,26629861,3188916,22240079,30734606,29787262,7728929,12832132,21956458,15953730,21334203,24485123,20712327,7070554,33328104,27458733,12825924,21936542,10071850,25683078,15597403,15225695,30878834,21561771,26130408,26037808,22985853,27213719,19703036,9005816,21413800,24124898,9191966,27390037,22344550,9258357,15878795,9109166,22130133,24769040,9083492,26670841,27474925,23664877,26401847,22130132,15908051,15012985,10464011,30991189,27554444,19560363,12812497,26518975,31176699,24917121,23107363,25610955,24863745,22892346,7799402,21963303,21604672,21534534,20884214,21920638,11462982,25937258,30909399,9584693,16170050,15808450,23124219,29032031,24607591,22450132,18835166,14556785,24915291,29587221,21208698,31287621,20687609,15274321,24875448,20429775,6928967,15862352,11754578,22265838,31679978,7658454,21890248,11448221,29274493,22832269,23434139,21888390,21177375,29886325,18771252,33182318,15149673,7733634,15210072,20117005,29741139,15978806,23577115,28068599,22112314,25659752,23023518,33380305,30508666,3449094,864277,19449526,9042245,21345671,20875738,36193872,25461320,8687103,20183604,11063616,15993583,21985639,15902462,14695837,15225692,24763261,23818757,9990460,27539315,30207239,9042226,24681390,29146452,24129617,20673627,18092832,6955006,21109944,20056543,15642411,26235945,24111942,25456085,2357265,25435253,19884770,20188119,5885064,15358288,15640952,9398595,15925513,15161020,19666584,24469112,12729639,20882962,10991861,15990302,14613327,28882321,26112445,18841351,20621731,14623005,7626163,11337102,3708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Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.

Gangjee A, Zeng Y, Ihnat M, Warnke LA, Green DW, Kisliuk RL, Lin FT. Gangjee A, et al. Bioorg Med Chem. 2005 Sep 15;13(18):5475-91. doi: 10.1016/j.bmc.2005.04.087. Bioorg Med Chem. 2005. PMID: 16039863

2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.

Gangjee A, Vasudevan A, Queener SF, Kisliuk RL. Gangjee A, et al. J Med Chem. 1996 Mar 29;39(7):1438-46. doi: 10.1021/jm950786p. J Med Chem. 1996. PMID: 8691474

Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.

Gangjee A, Adair OO, Queener SF. Gangjee A, et al. J Med Chem. 2003 Nov 6;46(23):5074-82. doi: 10.1021/jm030312n. J Med Chem. 2003. PMID: 14584957

Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.

Gangjee A, Adair O, Queener SF. Gangjee A, et al. J Med Chem. 1999 Jul 1;42(13):2447-55. doi: 10.1021/jm990079m. J Med Chem. 1999. PMID: 10395486

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.

Gangjee A, Lin X, Kisliuk RL, McGuire JJ. Gangjee A, et al. J Med Chem. 2005 Nov 17;48(23):7215-22. doi: 10.1021/jm058234m. J Med Chem. 2005. PMID: 16279780

Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.

Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W. Gangjee A, et al. J Med Chem. 1998 Aug 27;41(18):3426-34. doi: 10.1021/jm980081y. J Med Chem. 1998. PMID: 9719595

Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.

Gangjee A, Elzein E, Queener SF, McGuire JJ. Gangjee A, et al. J Med Chem. 1998 Apr 23;41(9):1409-16. doi: 10.1021/jm9705420. J Med Chem. 1998. PMID: 9554874

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ. Robson C, et al. J Med Chem. 1997 Sep 12;40(19):3040-8. doi: 10.1021/jm970055k. J Med Chem. 1997. PMID: 9301666

New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.

Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF. Rosowsky A, et al. J Med Chem. 2004 Mar 11;47(6):1475-86. doi: 10.1021/jm030438k. J Med Chem. 2004. PMID: 14998335

Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.

Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W. Gangjee A, et al. J Med Chem. 1998 Apr 9;41(8):1263-71. doi: 10.1021/jm970537w. J Med Chem. 1998. PMID: 9548816

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