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Items: 1 to 20 of 118

1.

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10315-20. Epub 2005 Jul 8.

2.

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH.

J Biol Chem. 2010 Aug 13;285(33):25161-7. doi: 10.1074/jbc.M110.103432. Epub 2010 Jun 4.

3.

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH.

J Biol Chem. 2005 Oct 7;280(40):34218-23. Epub 2005 Aug 4.

4.

Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.

Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23.

5.

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D.

Mol Endocrinol. 2005 Dec;19(12):3073-84. Epub 2005 Aug 11.

PMID:
16099816
6.

Regulation of a third conserved phosphorylation site in SGK1.

Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH.

J Biol Chem. 2009 Feb 6;284(6):3453-60. doi: 10.1074/jbc.M807502200. Epub 2008 Dec 9.

7.

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.

Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR.

J Clin Invest. 2015 Sep;125(9):3433-48. doi: 10.1172/JCI75245. Epub 2015 Aug 4.

8.

The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.

Náray-Fejes-Tóth A, Snyder PM, Fejes-Tóth G.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17434-9. Epub 2004 Dec 6.

9.

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S.

Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12.

PMID:
24821705
10.

14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.

Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T, Ichimura T.

Biochemistry. 2006 May 30;45(21):6733-40.

PMID:
16716084
11.

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T.

J Biol Chem. 2005 Apr 1;280(13):13187-94. Epub 2005 Jan 26.

12.

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR.

J Biol Chem. 2006 Sep 8;281(36):26159-69. Epub 2006 Jul 14.

13.

Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.

Cheng CJ, Huang CL.

J Am Soc Nephrol. 2011 Mar;22(3):460-71. doi: 10.1681/ASN.2010060681. Epub 2011 Feb 25.

14.

Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1.

Henke G, Maier G, Wallisch S, Boehmer C, Lang F.

J Cell Physiol. 2004 May;199(2):194-9.

PMID:
15040001
15.

Regulation of the epithelial sodium channel by accessory proteins.

Gormley K, Dong Y, Sagnella GA.

Biochem J. 2003 Apr 1;371(Pt 1):1-14. Review.

16.

Regulation of epithelial Na+ channels by aldosterone: role of Sgk1.

Lee IH, Campbell CR, Cook DI, Dinudom A.

Clin Exp Pharmacol Physiol. 2008 Feb;35(2):235-41. doi: 10.1111/j.1440-1681.2007.04844.x. Review.

PMID:
18197893
17.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93. Epub 2005 Oct 31.

18.

Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB.

Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC, Lang F.

Obes Res. 2004 May;12(5):862-70.

19.

Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

Liu Z, Wang HR, Huang CL.

J Biol Chem. 2009 May 1;284(18):12198-206. doi: 10.1074/jbc.M806551200. Epub 2009 Feb 25.

20.

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Lazrak A, Liu Z, Huang CL.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1615-20. Epub 2006 Jan 20.

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