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Items: 1 to 20 of 270

1.

Detoxification of organophosphate nerve agents by bacterial phosphotriesterase.

Ghanem E, Raushel FM.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):459-70. Review.

PMID:
15982683
2.

Bacterial detoxification of organophosphate nerve agents.

Raushel FM.

Curr Opin Microbiol. 2002 Jun;5(3):288-95. Review.

PMID:
12057683
3.

Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning.

Masson P, Josse D, Lockridge O, Viguié N, Taupin C, Buhler C.

J Physiol Paris. 1998 Oct-Dec;92(5-6):357-62. Review.

PMID:
9789837
4.

Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.

Tsai PC, Fox N, Bigley AN, Harvey SP, Barondeau DP, Raushel FM.

Biochemistry. 2012 Aug 14;51(32):6463-75. Epub 2012 Jul 31.

5.

Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers.

Xiang DF, Bigley AN, Ren Z, Xue H, Hull KG, Romo D, Raushel FM.

Biochemistry. 2015 Dec 29;54(51):7539-49. doi: 10.1021/acs.biochem.5b01144. Epub 2015 Dec 16.

6.

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.

Hill CM, Li WS, Thoden JB, Holden HM, Raushel FM.

J Am Chem Soc. 2003 Jul 30;125(30):8990-1.

PMID:
15369336
7.

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters.

Briseño-Roa L, Timperley CM, Griffiths AD, Fersht AR.

Protein Eng Des Sel. 2011 Jan;24(1-2):151-9. doi: 10.1093/protein/gzq076. Epub 2010 Oct 30.

PMID:
21037279
8.

Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design.

Melzer M, Chen JC, Heidenreich A, Gäb J, Koller M, Kehe K, Blum MM.

J Am Chem Soc. 2009 Dec 2;131(47):17226-32. doi: 10.1021/ja905444g.

PMID:
19894712
9.

Update on biochemical properties of recombinant Pseudomonas diminuta phosphotriesterase.

Carletti E, Jacquamet L, Loiodice M, Rochu D, Masson P, Nachon F.

J Enzyme Inhib Med Chem. 2009 Aug;24(4):1045-55. doi: 10.1080/14756360802608518.

PMID:
19548794
10.

Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.

Goldsmith M, Eckstein S, Ashani Y, Greisen P Jr, Leader H, Sussman JL, Aggarwal N, Ovchinnikov S, Tawfik DS, Baker D, Thiermann H, Worek F.

Arch Toxicol. 2016 Nov;90(11):2711-2724. Epub 2015 Nov 26.

PMID:
26612364
11.

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase.

Tsai PC, Bigley A, Li Y, Ghanem E, Cadieux CL, Kasten SA, Reeves TE, Cerasoli DM, Raushel FM.

Biochemistry. 2010 Sep 21;49(37):7978-87. doi: 10.1021/bi101056m.

12.

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.

Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041. Epub 2011 Jun 12.

PMID:
21683774
13.

Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.

Meier MM, Rajendran C, Malisi C, Fox NG, Xu C, Schlee S, Barondeau DP, Höcker B, Sterner R, Raushel FM.

J Am Chem Soc. 2013 Aug 7;135(31):11670-7. doi: 10.1021/ja405911h. Epub 2013 Jul 29.

14.

Activation of the binuclear metal center through formation of phosphotriesterase-inhibitor complexes.

Samples CR, Raushel FM, DeRose VJ.

Biochemistry. 2007 Mar 20;46(11):3435-42. Epub 2007 Feb 22.

PMID:
17315951
16.

Hyperthermophilic phosphotriesterases/lactonases for the environment and human health.

Mandrich L, Merone L, Manco G.

Environ Technol. 2010 Sep;31(10):1115-27. doi: 10.1080/09593331003789529.

PMID:
20718294
17.

Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR.

Bigley AN, Mabanglo MF, Harvey SP, Raushel FM.

Biochemistry. 2015 Sep 8;54(35):5502-12. doi: 10.1021/acs.biochem.5b00629. Epub 2015 Aug 25.

PMID:
26274608
18.

Phosphotriesterase: a complementary tool for the selective detection of two organophosphate insecticides: chlorpyrifos and chlorfenvinfos.

Istamboulie G, Fournier D, Marty JL, Noguer T.

Talanta. 2009 Mar 15;77(5):1627-31. doi: 10.1016/j.talanta.2008.09.050. Epub 2008 Oct 14.

PMID:
19159775
19.

Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans.

Hawwa R, Larsen SD, Ratia K, Mesecar AD.

J Mol Biol. 2009 Oct 16;393(1):36-57. doi: 10.1016/j.jmb.2009.06.083. Epub 2009 Jul 22.

PMID:
19631223
20.

Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase.

Merone L, Mandrich L, Porzio E, Rossi M, Müller S, Reiter G, Worek F, Manco G.

Bioresour Technol. 2010 Dec;101(23):9204-12. doi: 10.1016/j.biortech.2010.06.102. Epub 2010 Jul 27.

PMID:
20667718

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