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Items: 1 to 20 of 190

1.

Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.

Kaila N, Somers WS, Thomas BE, Thakker P, Janz K, DeBernardo S, Tam S, Moore WJ, Yang R, Wrona W, Bedard PW, Crommie D, Keith JC Jr, Tsao DH, Alvarez JC, Ni H, Marchese E, Patton JT, Magnani JL, Camphausen RT.

J Med Chem. 2005 Jun 30;48(13):4346-57.

PMID:
15974587
2.

Sialyl Lewis(x) analogs based on a quinic acid scaffold as the fucose mimic.

Girard C, Dourlat J, Savarin A, Surcin C, Leue S, Escriou V, Largeau C, Herscovici J, Scherman D.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3224-8.

PMID:
15936191
3.

Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin.

Beauharnois ME, Lindquist KC, Marathe D, Vanderslice P, Xia J, Matta KL, Neelamegham S.

Biochemistry. 2005 Jul 12;44(27):9507-19.

PMID:
15996105
4.

Structure--activity relationships of sialyl Lewis x-containing oligosaccharides. 1. Effect of modifications of the fucose moiety.

Ramphal JY, Zheng ZL, Perez C, Walker LE, DeFrees SA, Gaeta FC.

J Med Chem. 1994 Oct 14;37(21):3459-63.

PMID:
7523674
5.

Ligand interactions with E-selectin. Identification of a new binding site for recognition of N-acyl aromatic glucosamine substituents of sialyl Lewis X.

Ramphal JY, Hiroshige M, Lou B, Gaudino JJ, Hayashi M, Chen SM, Chiang LC, Gaeta FC, DeFrees SA.

J Med Chem. 1996 Mar 29;39(7):1357-60.

PMID:
8691465
6.

Rational design and synthesis of small molecule, non-oligosaccharide selectin inhibitors: (alpha-D-mannopyranosyloxy)biphenyl-substituted carboxylic acids.

Kogan TP, Dupré B, Keller KM, Scott IL, Bui H, Market RV, Beck PJ, Voytus JA, Revelle BM, Scott D.

J Med Chem. 1995 Dec 22;38(26):4976-84.

PMID:
8544173
8.

Design and synthesis of sialyl Lewis(x) mimics as E- and P-selectin inhibitors.

Kaila N, Thomas BE 4th.

Med Res Rev. 2002 Nov;22(6):566-601. Review.

PMID:
12369089
9.

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.

Thoma G, Magnani JL, Patton JT.

Bioorg Med Chem Lett. 2001 Apr 9;11(7):923-5.

PMID:
11294392
10.

Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin.

Lin CH, Shimazaki M, Wong CH, Koketsu M, Juneja LR, Kim M.

Bioorg Med Chem. 1995 Dec;3(12):1625-30.

PMID:
8770386
11.

Studies on selectin blockers. 4. Structure-function relationships of sulfated sialyl Lewis X hexasaccharide ceramides toward E-, P-, and L-selectin binding.

Yoshino K, Ohmoto H, Kondo N, Tsujishita H, Hiramatsu Y, Inoue Y, Kondo H.

J Med Chem. 1997 Feb 14;40(4):455-62.

PMID:
9046335
12.

Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.

Kaila N, Thomas BE 4th, Thakker P, Alvarez JC, Camphausen RT, Crommie D.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):151-5.

PMID:
11206447
13.

Chemoenzymatic synthesis of sialyl-trimeric-Lewis x.

Koeller KM, Wong CH.

Chemistry. 2000 Apr 3;6(7):1243-51.

PMID:
10785811
14.

Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics.

Titz A, Patton J, Smiesko M, Radic Z, Schwardt O, Magnani JL, Ernst B.

Bioorg Med Chem. 2010 Jan 1;18(1):19-27. doi: 10.1016/j.bmc.2009.11.024. Epub 2009 Nov 13.

PMID:
19948406
16.

Beta-C-mannosides as selectin inhibitors.

Kaila N, Chen L, Thomas BE 4th, Tsao D, Tam S, Bedard PW, Camphausen RT, Alvarez JC, Ullas G.

J Med Chem. 2002 Apr 11;45(8):1563-6.

PMID:
11931610
17.

Design and synthesis of C-linked fucosides as inhibitors of E-selectin.

Uchiyama T, Woltering TJ, Wong W, Lin CC, Kajimoto T, Takebayashi M, Weitz-Schmidt G, Asakura T, Noda M, Wong CH.

Bioorg Med Chem. 1996 Jul;4(7):1149-65.

PMID:
8831987
18.

Synthesis and biological evaluation of a potent E-selectin antagonist.

Thoma G, Kinzy W, Bruns C, Patton JT, Magnani JL, Bänteli R.

J Med Chem. 1999 Nov 18;42(23):4909-13.

PMID:
10579852
19.

Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity.

Rao BN, Anderson MB, Musser JH, Gilbert JH, Schaefer ME, Foxall C, Brandley BK.

J Biol Chem. 1994 Aug 5;269(31):19663-6.

20.

Multivalent display of quinic acid based ligands for targeting E-selectin expressing cells.

Shamay Y, Paulin D, Ashkenasy G, David A.

J Med Chem. 2009 Oct 8;52(19):5906-15. doi: 10.1021/jm900308r.

PMID:
19746918

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