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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ.

Mol Cell Biol. 2005 Jul;25(13):5675-86.


Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER.

Hum Mol Genet. 2001 May 1;10(10):1029-38.


Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.

Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI; Tumor and Angiogenesis Research Group.

Cancer. 2002 Sep 1;95(5):1055-63.


Nuclear localization of hypoxia-inducible factor-2alpha in bovine arterial endothelial cells.

Hara S, Kobayashi C, Imura N.

Mol Cell Biol Res Commun. 1999 Aug;2(2):119-23.


Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.

Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M.

Carcinogenesis. 2007 Mar;28(3):529-36. Epub 2006 Aug 18.


Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL.

Cancer Res. 2003 Oct 1;63(19):6130-4. Erratum in: Cancer Res. 2003 Dec 1;63(23):8562.


Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).

Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I.

J Biol Chem. 2003 Feb 28;278(9):7520-30. Epub 2002 Dec 2.


Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor.

Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L.

Proc Natl Acad Sci U S A. 1997 May 27;94(11):5667-72.


Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular development.

Freeburg PB, Robert B, St John PL, Abrahamson DR.

J Am Soc Nephrol. 2003 Apr;14(4):927-38.


Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.

Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S.

Cancer Res. 2005 Jun 15;65(12):5221-30.


Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

Wiesener MS, Münchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jürgensen JS, Gruber G, Maxwell PH, Löning SA, Frei U, Maher ER, Gröne HJ, Eckardt KU.

Cancer Res. 2001 Jul 1;61(13):5215-22.


Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.

Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC.

Mol Cancer Ther. 2008 Jul;7(7):1974-84. doi: 10.1158/1535-7163.MCT-07-2059.


Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS.

Cancer Res. 2005 Jul 1;65(13):5881-9.


Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

Schödel J, Grampp S, Maher ER, Moch H, Ratcliffe PJ, Russo P, Mole DR.

Eur Urol. 2016 Apr;69(4):646-57. doi: 10.1016/j.eururo.2015.08.007. Epub 2015 Aug 19. Review.


Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms' tumor.

Karth J, Ferrer FA, Perlman E, Hanrahan C, Simons JW, Gearhart JP, Rodriguez R.

J Pediatr Surg. 2000 Dec;35(12):1749-53.


[The expression of hypoxia inducible factor-1,2 alpha in sporadic clear cell renal cell carcinoma and their relationships to the mutations of von Hippel-Lindau gene].

Gong K, Zhang N, Na X, Wu G, Yang XY, Xin DQ, Na YQ.

Zhonghua Wai Ke Za Zhi. 2005 Mar 15;43(6):390-3. Chinese.


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