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The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells.

Ma BY, Mikolajczak SA, Danesh A, Hosiawa KA, Cameron CM, Takaori-Kondo A, Uchiyama T, Kelvin DJ, Ochi A.

Blood. 2005 Sep 15;106(6):2002-10. Epub 2005 Jun 7.


4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

Dawicki W, Bertram EM, Sharpe AH, Watts TH.

J Immunol. 2004 Nov 15;173(10):5944-51.


Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses.

Taraban VY, Rowley TF, O'Brien L, Chan HT, Haswell LE, Green MH, Tutt AL, Glennie MJ, Al-Shamkhani A.

Eur J Immunol. 2002 Dec;32(12):3617-27.


During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.

Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, Borst J.

J Immunol. 2005 Aug 1;175(3):1665-76.


4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.

Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB.

Immunology. 2004 Aug;112(4):559-66.


Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

Lee SW, Park Y, Song A, Cheroutre H, Kwon BS, Croft M.

J Immunol. 2006 Oct 1;177(7):4464-72.


Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes.

Nam KO, Kang H, Shin SM, Cho KH, Kwon B, Kwon BS, Kim SJ, Lee HW.

J Immunol. 2005 Feb 15;174(4):1898-905.


4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells.

Laderach D, Movassagh M, Johnson A, Mittler RS, Galy A.

Int Immunol. 2002 Oct;14(10):1155-67.


4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.

Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS.

J Exp Med. 1997 Jul 7;186(1):47-55.


4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells.

Choi BK, Bae JS, Choi EM, Kang WJ, Sakaguchi S, Vinay DS, Kwon BS.

J Leukoc Biol. 2004 May;75(5):785-91. Epub 2003 Dec 23.


Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells.

Kanamaru F, Youngnak P, Hashiguchi M, Nishioka T, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M.

J Immunol. 2004 Jun 15;172(12):7306-14.


Modulation of cord blood CD8+ T-cell effector differentiation by TGF-beta1 and 4-1BB costimulation.

Kim YJ, Stringfield TM, Chen Y, Broxmeyer HE.

Blood. 2005 Jan 1;105(1):274-81. Epub 2004 Sep 7.


Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling.

Sun Y, Blink SE, Chen JH, Fu YX.

J Immunol. 2005 Jul 15;175(2):884-90.


Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.

Tan JT, Ha J, Cho HR, Tucker-Burden C, Hendrix RC, Mittler RS, Pearson TC, Larsen CP.

Transplantation. 2000 Jul 15;70(1):175-83.


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