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Items: 1 to 20 of 382

1.

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.

Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T.

Biochemistry. 2005 Jun 14;44(23):8312-25.

PMID:
15938621
2.

Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis.

Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.

Cell Signal. 2001 Mar;13(3):159-67.

PMID:
11282454
3.

Implications of PDE4 structure on inhibitor selectivity across PDE families.

Ke H.

Int J Impot Res. 2004 Jun;16 Suppl 1:S24-7. Review.

PMID:
15224132
4.
5.

Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5.

Sopory S, Balaji S, Srinivasan N, Visweswariah SS.

FEBS Lett. 2003 Mar 27;539(1-3):161-6.

6.

Crystal structure of phosphodiesterase 4D and inhibitor complex(1).

Lee ME, Markowitz J, Lee JO, Lee H.

FEBS Lett. 2002 Oct 23;530(1-3):53-8.

7.

Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase.

Huang D, Hinds TR, Martinez SE, Doneanu C, Beavo JA.

J Biol Chem. 2004 Nov 12;279(46):48143-51. Epub 2004 Aug 25.

8.

Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.

Scapin G, Patel SB, Chung C, Varnerin JP, Edmondson SD, Mastracchio A, Parmee ER, Singh SB, Becker JW, Van der Ploeg LH, Tota MR.

Biochemistry. 2004 May 25;43(20):6091-100.

PMID:
15147193
9.

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

Wang H, Liu Y, Chen Y, Robinson H, Ke H.

J Biol Chem. 2005 Sep 2;280(35):30949-55. Epub 2005 Jul 1.

10.

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT.

J Mol Biol. 2004 Mar 19;337(2):355-65.

PMID:
15003452
11.

Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.

Cheung PP, Yu L, Zhang H, Colman RW.

Arch Biochem Biophys. 1998 Dec 1;360(1):99-104.

PMID:
9826434
12.

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.

Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.

Cell Signal. 2001 Apr;13(4):287-97.

PMID:
11306246
13.

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H.

Structure. 2003 Jul;11(7):865-73.

14.
15.

Identification of inhibitor specificity determinants in a mammalian phosphodiesterase.

Atienza JM, Susanto D, Huang C, McCarty AS, Colicelli J.

J Biol Chem. 1999 Feb 19;274(8):4839-47.

16.
17.

Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1).

Kakkar R, Raju RV, Sharma RK.

Cell Mol Life Sci. 1999 Jul;55(8-9):1164-86. Review.

PMID:
10442095
18.
19.

Cyclic nucleotide phosphodiesterases: relating structure and function.

Francis SH, Turko IV, Corbin JD.

Prog Nucleic Acid Res Mol Biol. 2001;65:1-52. Review.

PMID:
11008484
20.

Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors.

Saldou N, Obernolte R, Huber A, Baecker PA, Wilhelm R, Alvarez R, Li B, Xia L, Callan O, Su C, Jarnagin K, Shelton ER.

Cell Signal. 1998 Jun;10(6):427-40.

PMID:
9720765

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