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Items: 1 to 20 of 113

1.

Achievement of behavioral efficacy and improved potency in new heterocyclic analogs of benzofuran H3 antagonists.

Cowart M, Faghih R, Gfesser G, Curtis M, Sun M, Zhao C, Bennani Y, Wetter J, Marsh K, Miller TR, Krueger K, Pan JB, Drescher K, Fox GB, Esbenshade TA, Hancock AA.

Inflamm Res. 2005 Apr;54 Suppl 1:S25-6. No abstract available.

PMID:
15928820
2.

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.

Cowart M, Gfesser GA, Browman KE, Faghih R, Miller TR, Milicic I, Baranowski JL, Krueger KM, Witte DG, Molesky AL, Komater VA, Buckley MJ, Diaz GJ, Gagne GD, Zhou D, Deng X, Pan L, Roberts EM, Diehl MS, Wetter JM, Marsh KC, Fox GB, Brioni JD, Esbenshade TA, Hancock AA.

Biochem Pharmacol. 2007 Apr 15;73(8):1243-55. Epub 2007 Feb 23.

PMID:
17371699
3.

Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.

Cowart M, Altenbach R, Black L, Faghih R, Zhao C, Hancock AA.

Mini Rev Med Chem. 2004 Nov;4(9):979-92. Review.

PMID:
15544558
4.

Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.

Sun M, Zhao C, Gfesser GA, Thiffault C, Miller TR, Marsh K, Wetter J, Curtis M, Faghih R, Esbenshade TA, Hancock AA, Cowart M.

J Med Chem. 2005 Oct 6;48(20):6482-90. Erratum in: J Med Chem. 2012 Jan 12;55(1):563.

PMID:
16190774
5.

4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.

Cowart M, Faghih R, Curtis MP, Gfesser GA, Bennani YL, Black LA, Pan L, Marsh KC, Sullivan JP, Esbenshade TA, Fox GB, Hancock AA.

J Med Chem. 2005 Jan 13;48(1):38-55.

PMID:
15634000
6.

Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.

Hancock AA, Diehl MS, Fey TA, Bush EN, Faghih R, Miller TR, Krueger KM, Pratt JK, Cowart MD, Dickinson RW, Shapiro R, Knourek-Segel VE, Droz BA, McDowell CA, Krishna G, Brune ME, Esbenshade TA, Jacobson PB.

Inflamm Res. 2005 Apr;54 Suppl 1:S27-9. No abstract available.

PMID:
15928821
7.

Fluorescent benzofuran histamine H(3) receptor antagonists with sub-nanomolar potency.

Cowart M, Gfesser GA, Bhatia K, Esser R, Sun M, Miller TR, Krueger K, Witte D, Esbenshade TA, Hancock AA.

Inflamm Res. 2006 Apr;55 Suppl 1:S47-8. No abstract available.

PMID:
16705379
8.

The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

Zhao C, Sun M, Bennani YL, Gopalakrishnan SM, Witte DG, Miller TR, Krueger KM, Browman KE, Thiffault C, Wetter J, Marsh KC, Hancock AA, Esbenshade TA, Cowart MD.

J Med Chem. 2008 Sep 11;51(17):5423-30. doi: 10.1021/jm8003625. Epub 2008 Aug 7.

PMID:
18683917
9.

Discovery of a series of potent arylthiadiazole H(3) antagonists.

Xiao D, Palani A, Sofolarides M, Huang Y, Aslanian R, Vaccaro H, Hong L, McKittrick B, West RE Jr, Williams SM, Wu RL, Hwa J, Sondey C, Lachowicz J.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):861-4. doi: 10.1016/j.bmcl.2010.11.065. Epub 2010 Nov 21.

PMID:
21186123
10.

Novel H3 receptor antagonists with improved pharmacokinetic profiles.

Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Semple G, Ren A, Pereira G, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Lorea J, Grottick AJ.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4133-6. doi: 10.1016/j.bmcl.2008.05.086. Epub 2008 May 24.

PMID:
18554904
11.

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.

Cowart M, Pratt JK, Stewart AO, Bennani YL, Esbenshade TA, Hancock AA.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):689-93.

PMID:
14741270
12.

Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia.

Fox GB, Esbenshade TA, Pan JB, Browman KE, Zhang M, Ballard ME, Radek RJ, Miner H, Bitner RS, Krueger KM, Yao BB, Faghih R, Rueter LE, Komater VA, Drescher KU, Buckley MJ, Sullivan JP, Cowart MD, Decker MW, Hancock AA.

Inflamm Res. 2005 Apr;54 Suppl 1:S23-4. No abstract available.

PMID:
15928819
13.

Structure-activity relationships of A-331440: a new histamine-3 antagonist with anti-obesity properties.

Faghih R, Esbenshade TA, Krueger KM, Yao BB, Witte DG, Miller TM, Kang CH, Fox GB, Cowart M, Bennani YL, Hancock AA.

Inflamm Res. 2004 Mar;53 Suppl 1:S79-80. Epub 2004 Mar 5. No abstract available.

PMID:
15054629
14.

Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists.

Stark H, Kathmann M, Schlicker E, Schunack W, Schlegel B, Sippl W.

Mini Rev Med Chem. 2004 Nov;4(9):965-77. Review.

PMID:
15544557
15.

Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.

Gfesser GA, Zhang H, Dinges J, Fox GB, Pan JB, Esbenshade TA, Yao BB, Witte D, Miller TR, Kang CH, Krueger KM, Bennani YL, Hancock AA, Faghih R.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):673-6.

PMID:
14741266
16.

Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists.

Berlin M, Lee YJ, Boyce CW, Wang Y, Aslanian R, McCormick KD, Sorota S, Williams SM, West RE Jr, Korfmacher W.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2359-64. doi: 10.1016/j.bmcl.2010.01.121. Epub 2010 Jan 28.

PMID:
20188550
17.

Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists.

Dastmalchi S, Hamzeh-Mivehroud M, Ghafourian T, Hamzeiy H.

J Mol Graph Model. 2008 Jan;26(5):834-44. Epub 2007 May 16.

PMID:
17561422
18.

2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.

Zaragoza F, Stephensen H, Peschke B, Rimvall K.

J Med Chem. 2005 Jan 13;48(1):306-11.

PMID:
15634025
19.

The medicinal chemistry of novel H(3) antagonists.

Cowart M, Faghih R, Gfesser G, Curtis M, Pratt JK, Bennani Y, Fox GB, Esbenshade TA, Hancock AA.

Inflamm Res. 2004 Mar;53 Suppl 1:S69-70. Epub 2004 Mar 5. No abstract available.

PMID:
15054624
20.

A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.

Cowart M, Sun M, Zhao C, Witte DG, Miller TR, Krueger KM, Browman K, Fox GB, Bennani YL, Esbenshade TA, Hancock AA.

Inflamm Res. 2007 Apr;56 Suppl 1:S47-8. No abstract available.

PMID:
17806176

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