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Items: 1 to 20 of 136

1.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31.

2.

In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

Hawes BE, O'neill KA, Yao X, Crona JH, Davis HR Jr, Graziano MP, Altmann SW.

Mol Pharmacol. 2007 Jan;71(1):19-29. Epub 2006 Sep 27.

3.

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H.

Biochim Biophys Acta. 2007 Sep;1771(9):1140-7. Epub 2007 Jun 23.

PMID:
17689140
4.

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.

Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP.

Science. 2004 Feb 20;303(5661):1201-4.

5.

Extracellular loop C of NPC1L1 is important for binding to ezetimibe.

Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11140-5. doi: 10.1073/pnas.0800936105. Epub 2008 Aug 5.

6.

Transporters as drug targets: discovery and development of NPC1L1 inhibitors.

Betters JL, Yu L.

Clin Pharmacol Ther. 2010 Jan;87(1):117-21. doi: 10.1038/clpt.2009.209. Epub 2009 Nov 11. Review. Erratum in: Clin Pharmacol Ther. 2010 Jun;87(6):759.

PMID:
19907422
7.

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY.

Biochim Biophys Acta. 2007 Sep;1771(9):1132-9. Epub 2007 Mar 16.

8.

Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver.

Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, Li J, Yu L.

Biochim Biophys Acta. 2011 Sep;1811(9):549-55. doi: 10.1016/j.bbalip.2011.05.013. Epub 2011 Jun 12.

9.
10.

NPC1L1 and cholesterol transport.

Betters JL, Yu L.

FEBS Lett. 2010 Jul 2;584(13):2740-7. doi: 10.1016/j.febslet.2010.03.030. Epub 2010 Mar 19. Review.

11.

Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.

Xie C, Zhou ZS, Li N, Bian Y, Wang YJ, Wang LJ, Li BL, Song BL.

J Lipid Res. 2012 Oct;53(10):2092-101. Epub 2012 Jul 17.

12.

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

Ge L, Wang J, Qi W, Miao HH, Cao J, Qu YX, Li BL, Song BL.

Cell Metab. 2008 Jun;7(6):508-19. doi: 10.1016/j.cmet.2008.04.001.

13.

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):551-6. doi: 10.1073/pnas.1014434108. Epub 2010 Dec 27.

14.

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.

Xie P, Zhu H, Jia L, Ma Y, Tang W, Wang Y, Xue B, Shi H, Yu L.

Atherosclerosis. 2014 Dec;237(2):609-17. doi: 10.1016/j.atherosclerosis.2014.09.036. Epub 2014 Oct 17.

15.

Ezetimibe, a selective inhibitor of the transport of cholesterol.

Miura S, Saku K.

Intern Med. 2008;47(13):1165-70. Epub 2008 Jul 1. Review.

16.

Ezetimibe inhibits hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice.

Xie P, Jia L, Ma Y, Ou J, Miao H, Wang N, Guo F, Yazdanyar A, Jiang XC, Yu L.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):920-5. doi: 10.1161/ATVBAHA.112.301187. Epub 2013 Mar 7.

17.

Niemann-pick C1-like 1 mediates alpha-tocopherol transport.

Narushima K, Takada T, Yamanashi Y, Suzuki H.

Mol Pharmacol. 2008 Jul;74(1):42-9. doi: 10.1124/mol.107.043034. Epub 2008 Apr 10.

18.

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L.

J Clin Invest. 2007 Jul;117(7):1968-78.

19.

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.

Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW.

J Biol Chem. 2004 Aug 6;279(32):33586-92. Epub 2004 Jun 1.

20.

Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.

Weinglass AB, Köhler MG, Nketiah EO, Liu J, Schmalhofer W, Thomas A, Williams B, Beers L, Smith L, Hafey M, Bleasby K, Leone J, Tang YS, Braun M, Ujjainwalla F, McCann ME, Kaczorowski GJ, Garcia ML.

Mol Pharmacol. 2008 Apr;73(4):1072-84. doi: 10.1124/mol.107.043844. Epub 2008 Jan 10.

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