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Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.

Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT.

EMBO J. 2005 Jun 15;24(12):2064-74. Epub 2005 May 26.


Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex.

Fukai S, Matern HT, Jagath JR, Scheller RH, Brunger AT.

EMBO J. 2003 Jul 1;22(13):3267-78.


Ral GTPases regulate exocyst assembly through dual subunit interactions.

Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA.

J Biol Chem. 2003 Dec 19;278(51):51743-8. Epub 2003 Oct 2.


Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.

Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D.

Biochemistry. 2009 Mar 17;48(10):2192-206. doi: 10.1021/bi802129d.


The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.

Fenwick RB, Campbell LJ, Rajasekar K, Prasannan S, Nietlispach D, Camonis J, Owen D, Mott HR.

Structure. 2010 Aug 11;18(8):985-95. doi: 10.1016/j.str.2010.05.013.


Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.

Mott HR, Nietlispach D, Hopkins LJ, Mirey G, Camonis JH, Owen D.

J Biol Chem. 2003 May 9;278(19):17053-9. Epub 2003 Mar 6.


RalA-exocyst interaction mediates GTP-dependent exocytosis.

Wang L, Li G, Sugita S.

J Biol Chem. 2004 May 7;279(19):19875-81. Epub 2004 Feb 20.


RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.

Lalli G.

J Cell Sci. 2009 May 15;122(Pt 10):1499-506. doi: 10.1242/jcs.044339. Epub 2009 Apr 21.


The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.

Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ.

J Biol Chem. 2001 Aug 10;276(32):29792-7. Epub 2001 Jun 13.


Ral's engagement with the exocyst: breaking up is hard to do.

Chen XW, Saltiel AR.

Cell Cycle. 2011 Jul 15;10(14):2299-304. Epub 2011 Jul 15.


RalB mobilizes the exocyst to drive cell migration.

Rossé C, Hatzoglou A, Parrini MC, White MA, Chavrier P, Camonis J.

Mol Cell Biol. 2006 Jan;26(2):727-34.


Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.

Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ.

Mol Cell Biol. 2002 Mar;22(6):1714-22.


Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap.

Nicely NI, Kosak J, de Serrano V, Mattos C.

Structure. 2004 Nov;12(11):2025-36.


Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.

Peng W, Xu J, Guan X, Sun Y, Zhang XC, Li X, Rao Z.

Protein Cell. 2011 Apr;2(4):308-19. doi: 10.1007/s13238-011-1036-z. Epub 2011 Apr 14.


Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.

Spiczka KS, Yeaman C.

J Cell Sci. 2008 Sep 1;121(Pt 17):2880-91. doi: 10.1242/jcs.031641. Epub 2008 Aug 12.


Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.

Hazelett CC, Yeaman C.

PLoS One. 2012;7(6):e39602. doi: 10.1371/journal.pone.0039602. Epub 2012 Jun 22.


The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.

Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA.

Nat Cell Biol. 2013 Oct;15(10):1220-30. doi: 10.1038/ncb2847. Epub 2013 Sep 22.


Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.

Issaq SH, Lim KH, Counter CM.

Mol Cancer Res. 2010 Feb;8(2):223-31. doi: 10.1158/1541-7786.MCR-09-0189. Epub 2010 Feb 9.


Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway.

Kawato M, Shirakawa R, Kondo H, Higashi T, Ikeda T, Okawa K, Fukai S, Nureki O, Kita T, Horiuchi H.

J Biol Chem. 2008 Jan 4;283(1):166-74. Epub 2007 Oct 15.


The exocyst complex binds the small GTPase RalA to mediate filopodia formation.

Sugihara K, Asano S, Tanaka K, Iwamatsu A, Okawa K, Ohta Y.

Nat Cell Biol. 2002 Jan;4(1):73-8.


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