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Items: 1 to 20 of 507

1.

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.

Luo S, Vacher C, Davies JE, Rubinsztein DC.

J Cell Biol. 2005 May 23;169(4):647-56.

2.

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.

J Neurosci. 2002 Sep 15;22(18):7862-72.

3.
4.

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.

Schilling B, Gafni J, Torcassi C, Cong X, Row RH, LaFevre-Bernt MA, Cusack MP, Ratovitski T, Hirschhorn R, Ross CA, Gibson BW, Ellerby LM.

J Biol Chem. 2006 Aug 18;281(33):23686-97. Epub 2006 Jun 16.

5.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.

Cell. 2006 Jun 16;125(6):1179-91.

6.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

7.

Aggregation in Huntington's disease: insights through modelling.

Cajavec B, Bernard S, Herzel H.

Genome Inform. 2005;16(1):262-71.

PMID:
16362929
8.

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM.

J Biol Chem. 2004 May 7;279(19):20211-20. Epub 2004 Feb 23.

9.

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.

Omi K, Hachiya NS, Tanaka M, Tokunaga K, Kaneko K.

Neurosci Lett. 2008 Jan 24;431(1):45-50. Epub 2007 Nov 17.

PMID:
18078716
10.

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.

Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA.

J Neurosci. 2012 Jan 4;32(1):183-93. doi: 10.1523/JNEUROSCI.1305-11.2012.

11.

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.

J Neurosci. 2008 Mar 12;28(11):2783-92. doi: 10.1523/JNEUROSCI.0106-08.2008.

12.

A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.

Poirier MA, Jiang H, Ross CA.

Hum Mol Genet. 2005 Mar 15;14(6):765-74. Epub 2005 Feb 2.

PMID:
15689354
13.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.

PMID:
16150600
14.

Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain.

Toneff T, Mende-Mueller L, Wu Y, Hwang SR, Bundey R, Thompson LM, Chesselet MF, Hook V.

J Neurochem. 2002 Jul;82(1):84-92.

15.

Selective degeneration in YAC mouse models of Huntington disease.

Van Raamsdonk JM, Warby SC, Hayden MR.

Brain Res Bull. 2007 Apr 30;72(2-3):124-31. Epub 2006 Nov 16. Review.

PMID:
17352936
18.
19.

Mutant protein in Huntington disease is resistant to proteolysis in affected brain.

Dyer RB, McMurray CT.

Nat Genet. 2001 Nov;29(3):270-8.

PMID:
11600884
20.

Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.

Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S.

J Neurosci. 2008 Aug 27;28(35):8747-55. doi: 10.1523/JNEUROSCI.0973-08.2008.

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