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The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.

Esser C, Scheffner M, Höhfeld J.

J Biol Chem. 2005 Jul 22;280(29):27443-8. Epub 2005 May 23.


The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.

Ahmed SF, Deb S, Paul I, Chatterjee A, Mandal T, Chatterjee U, Ghosh MK.

J Biol Chem. 2012 May 4;287(19):15996-6006. doi: 10.1074/jbc.M111.321083. Epub 2012 Mar 15.


Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein).

Shimamoto S, Kubota Y, Yamaguchi F, Tokumitsu H, Kobayashi R.

J Biol Chem. 2013 Mar 8;288(10):7158-68. doi: 10.1074/jbc.M112.436758. Epub 2013 Jan 23.


CHIP chaperones wild type p53 tumor suppressor protein.

Tripathi V, Ali A, Bhat R, Pati U.

J Biol Chem. 2007 Sep 28;282(39):28441-54. Epub 2007 Jul 31.


The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity.

Paul I, Ahmed SF, Bhowmik A, Deb S, Ghosh MK.

Oncogene. 2013 Mar 7;32(10):1284-95. doi: 10.1038/onc.2012.144. Epub 2012 Apr 30.


Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling.

Demand J, Alberti S, Patterson C, Höhfeld J.

Curr Biol. 2001 Oct 16;11(20):1569-77.


Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase.

Xia T, Dimitropoulou C, Zeng J, Antonova GN, Snead C, Venema RC, Fulton D, Qian S, Patterson C, Papapetropoulos A, Catravas JD.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3080-7. Epub 2007 Sep 14.


The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.

Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH.

Mol Cell Biol. 1998 Mar;18(3):1517-24.


Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.

Li D, Marchenko ND, Schulz R, Fischer V, Velasco-Hernandez T, Talos F, Moll UM.

Mol Cancer Res. 2011 May;9(5):577-88. doi: 10.1158/1541-7786.MCR-10-0534. Epub 2011 Apr 8.


ErbB2 degradation mediated by the co-chaperone protein CHIP.

Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H.

J Biol Chem. 2003 Apr 18;278(16):13829-37. Epub 2003 Feb 6.


Chaperone-dependent stabilization and degradation of p53 mutants.

Muller P, Hrstka R, Coomber D, Lane DP, Vojtesek B.

Oncogene. 2008 May 29;27(24):3371-83. doi: 10.1038/sj.onc.1211010. Epub 2008 Jan 28.


CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.

Stankiewicz M, Nikolay R, Rybin V, Mayer MP.

FEBS J. 2010 Aug;277(16):3353-67. doi: 10.1111/j.1742-4658.2010.07737.x. Epub 2010 Jul 8.


Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase.

Yan W, Jung YS, Zhang Y, Chen X.

PLoS One. 2014 Aug 12;9(8):e103497. doi: 10.1371/journal.pone.0103497. eCollection 2014.


The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.

Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Höhfeld J, Patterson C.

Nat Cell Biol. 2001 Jan;3(1):93-6.


SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.

Li D, Marchenko ND, Moll UM.

Cell Death Differ. 2011 Dec;18(12):1904-13. doi: 10.1038/cdd.2011.71. Epub 2011 Jun 3.


Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

King FW, Wawrzynow A, Höhfeld J, Zylicz M.

EMBO J. 2001 Nov 15;20(22):6297-305.


CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

Urushitani M, Kurisu J, Tateno M, Hatakeyama S, Nakayama K, Kato S, Takahashi R.

J Neurochem. 2004 Jul;90(1):231-44.


Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP.

Wang J, Zhao Q, Qi Q, Gu HY, Rong JJ, Mu R, Zou MJ, Tao L, You QD, Guo QL.

J Cell Biochem. 2011 Feb;112(2):509-19. doi: 10.1002/jcb.22941.


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