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COX-2-derived prostacyclin modulates vascular remodeling.

Rudic RD, Brinster D, Cheng Y, Fries S, Song WL, Austin S, Coffman TM, FitzGerald GA.

Circ Res. 2005 Jun 24;96(12):1240-7. Epub 2005 May 19.


Role of prostacyclin in the cardiovascular response to thromboxane A2.

Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Grosser T, Lawson JA, FitzGerald GA.

Science. 2002 Apr 19;296(5567):539-41.


Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism.

Egan KM, Wang M, Fries S, Lucitt MB, Zukas AM, Puré E, Lawson JA, FitzGerald GA.

Circulation. 2005 Jan 25;111(3):334-42. Epub 2005 Jan 17. Erratum in: Circulation. 2005 May 10;111(18):2412. Fries, Susanne [added].


Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.

Hong TT, Huang J, Barrett TD, Lucchesi BR.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H145-55. Epub 2007 Oct 5.


Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice.

Praticò D, Tillmann C, Zhang ZB, Li H, FitzGerald GA.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3358-63. Epub 2001 Mar 6.


COX-2-derived prostacyclin confers atheroprotection on female mice.

Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA.

Science. 2004 Dec 10;306(5703):1954-7. Epub 2004 Nov 18.


Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis.

Belton OA, Duffy A, Toomey S, Fitzgerald DJ.

Circulation. 2003 Dec 16;108(24):3017-23. Epub 2003 Nov 24.


Prostaglandin I2 and prostaglandin E2 modulate human intrarenal artery contractility through prostaglandin E2-EP4, prostacyclin-IP, and thromboxane A2-TP receptors.

Eskildsen MP, Hansen PB, Stubbe J, Toft A, Walter S, Marcussen N, Rasmussen LM, Vanhoutte PM, Jensen BL.

Hypertension. 2014 Sep;64(3):551-6. doi: 10.1161/HYPERTENSIONAHA.113.03051. Epub 2014 Jun 9.


Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching.

Huang JC, Wun WS, Goldsby JS, Matijevic-Aleksic N, Wu KK.

Hum Reprod. 2004 Dec;19(12):2900-6. Epub 2004 Oct 15.


Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization.

Wilson SJ, Dowling JK, Zhao L, Carnish E, Smyth EM.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):290-6. Epub 2006 Nov 16.


Roles of cyclooxygenase-2 and prostacyclin/IP receptors in mucosal defense against ischemia/reperfusion injury in mouse stomach.

Kotani T, Kobata A, Nakamura E, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2006 Feb;316(2):547-55. Epub 2005 Oct 19.


Oviduct prostacyclin functions as a paracrine factor to augment the development of embryos.

Huang JC, Goldsby JS, Arbab F, Melhem Z, Aleksic N, Wu KK.

Hum Reprod. 2004 Dec;19(12):2907-12. Epub 2004 Oct 18.


A vasoconstrictor role for cyclooxygenase-1-mediated prostacyclin synthesis in mouse renal arteries.

Liu B, Zhang Y, Zhu N, Li H, Luo W, Zhou Y.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1315-22. doi: 10.1152/ajprenal.00332.2013. Epub 2013 Aug 28.


Estrogen stimulation of COX-2-derived PGI2 confers atheroprotection.

Shah BH.

Trends Endocrinol Metab. 2005 Jul;16(5):199-201. Review.


COX-2-dependent cardiac failure in Gh/tTG transgenic mice.

Zhang Z, Vezza R, Plappert T, McNamara P, Lawson JA, Austin S, Praticò D, Sutton MS, FitzGerald GA.

Circ Res. 2003 May 30;92(10):1153-61. Epub 2003 Apr 17.


Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta.

Martorell A, Blanco-Rivero J, Aras-López R, Sagredo A, Balfagón G, Ferrer M.

Cardiovasc Res. 2008 Feb 1;77(3):590-9. Epub 2007 Nov 5.


Cyclo-oxygenase products and atherothrombosis.

FitzGerald GA, Austin S, Egan K, Cheng Y, Pratico D.

Ann Med. 2000 Dec;32 Suppl 1:21-6. Review.


Eicosanoids and the vascular endothelium.

Egan K, FitzGerald GA.

Handb Exp Pharmacol. 2006;(176 Pt 1):189-211. Review.


Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.

Fujino T, Nakagawa N, Yuhki K, Hara A, Yamada T, Takayama K, Kuriyama S, Hosoki Y, Takahata O, Taniguchi T, Fukuzawa J, Hasebe N, Kikuchi K, Narumiya S, Ushikubi F.

J Clin Invest. 2004 Sep;114(6):805-12.

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