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Items: 1 to 20 of 120

1.

Substrate specificity of isopenicillin N synthase.

Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW.

J Med Chem. 1992 May 15;35(10):1897-914.

PMID:
1588566
4.

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.

Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2009 Aug 17;10(12):2025-31. doi: 10.1002/cbic.200900080.

PMID:
19598184
5.

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.

Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ.

Biochem J. 2003 Jun 15;372(Pt 3):687-93.

6.

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Biochem Biophys Res Commun. 2010 Aug 6;398(4):659-64. doi: 10.1016/j.bbrc.2010.06.129. Epub 2010 Jul 13.

PMID:
20603104
7.

The thioredoxin system of Penicillium chrysogenum and its possible role in penicillin biosynthesis.

Cohen G, Argaman A, Schreiber R, Mislovati M, Aharonowitz Y.

J Bacteriol. 1994 Feb;176(4):973-84.

9.

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2013 Mar 18;14(5):599-606. doi: 10.1002/cbic.201200728. Epub 2013 Mar 6.

PMID:
23468426
10.

Studies on the ring-cyclization and ring-expansion enzymes of beta-lactam biosynthesis in Cephalosporium acremonium.

Kupka J, Shen YQ, Wolfe S, Demain AL.

Can J Microbiol. 1983 May;29(5):488-96.

PMID:
6688373
11.

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

Howard-Jones AR, Elkins JM, Clifton IJ, Roach PL, Adlington RM, Baldwin JE, Rutledge PJ.

Biochemistry. 2007 Apr 24;46(16):4755-62. Epub 2007 Mar 31.

PMID:
17397141
12.

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Org Biomol Chem. 2010 Jan 7;8(1):122-7. doi: 10.1039/b910170e. Epub 2009 Oct 29.

PMID:
20024142
14.
15.
17.

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.

Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE.

Nature. 1999 Oct 14;401(6754):721-4.

PMID:
10537113
18.

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.

FEBS Lett. 2013 Aug 19;587(16):2705-9. doi: 10.1016/j.febslet.2013.07.016. Epub 2013 Jul 13.

20.

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