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The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.

Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH.

Blood. 2005 Aug 15;106(4):1314-22. Epub 2005 May 3.


Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG.

Nature. 2004 Jan 22;427(6972):355-60.


Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

Morris MA, Gibb DR, Picard F, Brinkmann V, Straume M, Ley K.

Eur J Immunol. 2005 Dec;35(12):3570-80.


FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Brinkmann V.

Br J Pharmacol. 2009 Nov;158(5):1173-82. doi: 10.1111/j.1476-5381.2009.00451.x. Epub 2009 Oct 8. Review.


FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.

Zhi L, Kim P, Thompson BD, Pitsillides C, Bankovich AJ, Yun SH, Lin CP, Cyster JG, Wu MX.

J Immunol. 2011 Sep 1;187(5):2244-51. doi: 10.4049/jimmunol.1100670. Epub 2011 Jul 25.


FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.

Honig SM, Fu S, Mao X, Yopp A, Gunn MD, Randolph GJ, Bromberg JS.

J Clin Invest. 2003 Mar;111(5):627-37.


A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.

Pereira JP, Xu Y, Cyster JG.

PLoS One. 2010 Feb 18;5(2):e9277. doi: 10.1371/journal.pone.0009277. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/2ae645ec-9413-4f7d-b51f-eb0678fa2f1b.


Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.

Pabst O, Herbrand H, Willenzon S, Worbs T, Schippers A, Müller W, Bernhardt G, Förster R.

J Immunol. 2006 Feb 1;176(3):1474-80.


Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.

Maeda Y, Seki N, Sato N, Sugahara K, Chiba K.

Int Immunol. 2010 Jun;22(6):515-25. doi: 10.1093/intimm/dxq036. Epub 2010 May 23.


The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

Sawicka E, Dubois G, Jarai G, Edwards M, Thomas M, Nicholls A, Albert R, Newson C, Brinkmann V, Walker C.

J Immunol. 2005 Dec 15;175(12):7973-80.


Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.

Matsuyuki H, Maeda Y, Yano K, Sugahara K, Chiba K, Kohno T, Igarashi Y.

Cell Mol Immunol. 2006 Dec;3(6):429-37.


[Effects of sphingosine 1-phosphate on functions of T cell - review].

Huang WR, Wang LS, DA WM.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Aug;13(4):718-22. Chinese.


CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720.

Henning G, Ohl L, Junt T, Reiterer P, Brinkmann V, Nakano H, Hohenberger W, Lipp M, Förster R.

J Exp Med. 2001 Dec 17;194(12):1875-81.


Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.

Chiba K, Matsuyuki H, Maeda Y, Sugahara K.

Cell Mol Immunol. 2006 Feb;3(1):11-9. Review.


Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.

Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H.

J Immunol. 2008 Apr 15;180(8):5335-43.


Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.

Singer II, Tian M, Wickham LA, Lin J, Matheravidathu SS, Forrest MJ, Mandala S, Quackenbush EJ.

J Immunol. 2005 Dec 1;175(11):7151-61.


Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.

Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T.

J Biol Chem. 2007 Mar 23;282(12):9082-9. Epub 2007 Jan 21.


Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Cyster JG, Schwab SR.

Annu Rev Immunol. 2012;30:69-94. doi: 10.1146/annurev-immunol-020711-075011. Epub 2011 Dec 5. Review.


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