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Items: 1 to 20 of 168

1.

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.

Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW.

J Cell Biol. 2005 Apr 25;169(2):331-9. Epub 2005 Apr 18.

2.

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

Nemoto S, Finkel T.

Science. 2002 Mar 29;295(5564):2450-2. Epub 2002 Mar 7.

4.

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection.

Wei W, Wang X, Kusiak JW.

J Biol Chem. 2002 May 17;277(20):17649-56. Epub 2002 Mar 6.

5.

The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.

Perrini S, Tortosa F, Natalicchio A, Pacelli C, Cignarelli A, Palmieri VO, Caccioppoli C, De Stefano F, Porro S, Leonardini A, Ficarella R, De Fazio M, Cocco T, Puglisi F, Laviola L, Palasciano G, Giorgino F.

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15;309(10):G826-40. doi: 10.1152/ajpgi.00041.2015. Epub 2015 Sep 3.

6.
7.

β-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway.

Bashir M, Parray AA, Baba RA, Bhat HF, Bhat SS, Mushtaq U, Andrabi KI, Khanday FA.

Neuromolecular Med. 2014 Mar;16(1):137-49. doi: 10.1007/s12017-013-8268-4. Epub 2013 Oct 2.

PMID:
24085465
8.

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.

Khanday FA, Yamamori T, Mattagajasingh I, Zhang Z, Bugayenko A, Naqvi A, Santhanam L, Nabi N, Kasuno K, Day BW, Irani K.

Mol Biol Cell. 2006 Jan;17(1):122-9. Epub 2005 Oct 26.

9.

ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.

Hu Y, Wang X, Zeng L, Cai DY, Sabapathy K, Goff SP, Firpo EJ, Li B.

Mol Biol Cell. 2005 Aug;16(8):3705-18. Epub 2005 Jun 1.

10.

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM.

J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009.

11.

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C145-52. Epub 2007 Nov 21.

12.

Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation.

Viana RJ, Ramalho RM, Nunes AF, Steer CJ, Rodrigues CM.

J Alzheimers Dis. 2010;22(2):557-68. doi: 10.3233/JAD-2010-100909.

PMID:
20847398
13.

The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death.

Akhter R, Sanphui P, Das H, Saha P, Biswas SC.

J Neurochem. 2015 Sep;134(6):1091-103. doi: 10.1111/jnc.13128. Epub 2015 Apr 28.

14.

Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease.

Smith WW, Gorospe M, Kusiak JW.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):355-61. Review.

PMID:
16787235
15.

Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins.

Li C, Xing G, Dong M, Zhou L, Li J, Wang G, Zou D, Wang R, Liu J, Niu Y.

Eur J Pharmacol. 2010 Jun 10;635(1-3):96-102. doi: 10.1016/j.ejphar.2010.03.013. Epub 2010 Mar 20.

PMID:
20307525
16.

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT.

Mol Cell Biol. 2004 Feb;24(4):1747-57.

17.

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

Wan J, Fu AK, Ip FC, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z, Ip NY.

J Neurosci. 2010 May 19;30(20):6873-81. doi: 10.1523/JNEUROSCI.0519-10.2010.

18.

3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling.

Telerman A, Ofir R, Kashman Y, Elmann A.

BMC Complement Altern Med. 2017 Jun 23;17(1):332. doi: 10.1186/s12906-017-1840-y.

19.

Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.

Yang CP, Horwitz SB.

Cancer Res. 2000 Sep 15;60(18):5171-8.

20.

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME.

J Neurosci. 2001 Oct 1;21(19):7551-60.

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