Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 92

1.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P.

Cancer Cell. 2005 Apr;7(4):325-36.

2.

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.

Cancer Res. 2001 Dec 15;61(24):8758-68.

3.
4.

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.

Alexandrov K, Simon I, Yurchenko V, Iakovenko A, Rostkova E, Scheidig AJ, Goody RS.

Eur J Biochem. 1999 Oct 1;265(1):160-70.

5.

Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.

Shen Q, Qin F, Gao Z, Cui J, Xiao H, Xu Z, Yang C.

Mol Cell Biol. 2009 Jul;29(14):3881-93. doi: 10.1128/MCB.01509-08. Epub 2009 May 4.

6.
9.
10.
11.

Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.

Brassard DL, English JM, Malkowski M, Kirschmeier P, Nagabhushan TL, Bishop WR.

Exp Cell Res. 2002 Feb 15;273(2):138-46.

PMID:
11822869
12.

Transgene-mediated cosuppression and RNA interference enhance germ-line apoptosis in Caenorhabditis elegans.

Adamo A, Woglar A, Silva N, Penkner A, Jantsch V, La Volpe A.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3440-5. doi: 10.1073/pnas.1107390109. Epub 2012 Feb 13.

13.

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.

Wu YW, Goody RS, Abagyan R, Alexandrov K.

J Biol Chem. 2009 May 8;284(19):13185-92. doi: 10.1074/jbc.M900579200. Epub 2009 Feb 24.

14.

Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells.

Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J.

Cell Mol Life Sci. 2001 Oct;58(11):1636-49. Review.

PMID:
11706990
15.

Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor.

Hu W, Wu W, Verschraegen CF, Chen L, Mao L, Yeung SC, Kudelka AP, Freedman RS, Kavanagh JJ.

Proteomics. 2003 Oct;3(10):1904-11.

PMID:
14625852
16.

Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.

Ageberg M, Rydström K, Lindén O, Linderoth J, Jerkeman M, Drott K.

Exp Cell Res. 2011 May 1;317(8):1179-91. doi: 10.1016/j.yexcr.2011.02.006. Epub 2011 Feb 13.

PMID:
21324313
17.

[Development of farsenyl transferase inhibitors as anticancer agents].

Cestac P, Doisneau-Sixou S, Favre G.

Ann Pharm Fr. 2005 Jan;63(1):76-84. Review. French.

PMID:
15803104
18.
19.

Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein.

Gutkowska M, Swiezewska E.

Mol Membr Biol. 2012 Nov;29(7):243-56. doi: 10.3109/09687688.2012.693211. Epub 2012 Jun 14. Review.

PMID:
22694141
20.

Biological effects and mechanism of action of farnesyl transferase inhibitors.

Ashar HR, Armstrong L, James LJ, Carr DM, Gray K, Taveras A, Doll RJ, Bishop WR, Kirschmeier PT.

Chem Res Toxicol. 2000 Oct;13(10):949-52. Review. No abstract available.

PMID:
11080039

Supplemental Content

Support Center