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Items: 1 to 20 of 154

1.

Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.

Delbos F, De Smet A, Faili A, Aoufouchi S, Weill JC, Reynaud CA.

J Exp Med. 2005 Apr 18;201(8):1191-6. Epub 2005 Apr 11.

2.

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA.

J Exp Med. 2007 Jan 22;204(1):17-23. Epub 2006 Dec 26.

3.

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

Faili A, Stary A, Delbos F, Weller S, Aoufouchi S, Sarasin A, Weill JC, Reynaud CA.

J Immunol. 2009 May 15;182(10):6353-9. doi: 10.4049/jimmunol.0900177.

4.

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Faili A, Aoufouchi S, Flatter E, Guéranger Q, Reynaud CA, Weill JC.

Nature. 2002 Oct 31;419(6910):944-7.

PMID:
12410315
5.

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination.

Martomo SA, Yang WW, Gearhart PJ.

J Exp Med. 2004 Jul 5;200(1):61-8.

6.

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.

Masuda K, Ouchida R, Hikida M, Kurosaki T, Yokoi M, Masutani C, Seki M, Wood RD, Hanaoka F, O-Wang J.

J Biol Chem. 2007 Jun 15;282(24):17387-94. Epub 2007 Apr 20.

7.

Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice.

Shimizu T, Azuma T, Ishiguro M, Kanjo N, Yamada S, Ohmori H.

Immunol Lett. 2005 May 15;98(2):259-64. Epub 2004 Dec 15.

PMID:
15860226
8.

Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.

Steele EJ, Franklin A, Blanden RV.

Immunol Cell Biol. 2004 Apr;82(2):209-18. Review. Erratum in: Immunol Cell Biol. 2004 Jun;82(3):342.

9.

Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.

Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ.

J Exp Med. 2004 Apr 5;199(7):917-24. Epub 2004 Mar 29.

10.

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

Pavlov YI, Rogozin IB, Galkin AP, Aksenova AY, Hanaoka F, Rada C, Kunkel TA.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9954-9. Epub 2002 Jul 15.

11.

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

Faili A, Aoufouchi S, Weller S, Vuillier F, Stary A, Sarasin A, Reynaud CA, Weill JC.

J Exp Med. 2004 Jan 19;199(2):265-70.

13.

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.

McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ.

J Exp Med. 2003 Aug 18;198(4):635-43.

14.

DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes.

Mayorov VI, Rogozin IB, Adkison LR, Gearhart PJ.

J Immunol. 2005 Jun 15;174(12):7781-6.

15.

Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs.

Steele EJ.

Mol Immunol. 2009 Jan;46(3):305-20. doi: 10.1016/j.molimm.2008.10.021. Epub 2008 Dec 4. Review.

PMID:
19062097
16.

The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.

Shimizu T, Shinkai Y, Ogi T, Ohmori H, Azuma T.

Immunol Lett. 2003 May 1;86(3):265-70.

PMID:
12706529
17.

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.

Bertocci B, De Smet A, Flatter E, Dahan A, Bories JC, Landreau C, Weill JC, Reynaud CA.

J Immunol. 2002 Apr 15;168(8):3702-6.

18.

UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.

Ohkumo T, Kondo Y, Yokoi M, Tsukamoto T, Yamada A, Sugimoto T, Kanao R, Higashi Y, Kondoh H, Tatematsu M, Masutani C, Hanaoka F.

Mol Cell Biol. 2006 Oct;26(20):7696-706. Epub 2006 Aug 5.

19.

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes.

González-Fernández A, Milstein C.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9862-6.

20.

Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process.

Bertocci B, Quint L, Delbos F, Garcia C, Reynaud CA, Weill JC.

Immunity. 1998 Aug;9(2):257-65.

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