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In vitro and in vivo antitumor effects of vitamin K5 on hepatocellular carcinoma.

Hitomi M, Nonomura T, Yokoyama F, Yoshiji H, Ogawa M, Nakai S, Deguchi A, Masaki T, Inoue H, Kimura Y, Kurokohchi K, Uchida N, Kuriyama S.

Int J Oncol. 2005 May;26(5):1337-44.


Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules.

Kuriyama S, Hitomi M, Yoshiji H, Nonomura T, Tsujimoto T, Mitoro A, Akahane T, Ogawa M, Nakai S, Deguchi A, Masaki T, Uchida N.

Int J Oncol. 2005 Aug;27(2):505-11.


Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo.

Hitomi M, Yokoyama F, Kita Y, Nonomura T, Masaki T, Yoshiji H, Inoue H, Kinekawa F, Kurokohchi K, Uchida N, Watanabe S, Kuriyama S.

Int J Oncol. 2005 Mar;26(3):713-20.


Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.

Ogawa M, Nakai S, Deguchi A, Nonomura T, Masaki T, Uchida N, Yoshiji H, Kuriyama S.

Int J Oncol. 2007 Aug;31(2):323-31.


Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo.

Cho SJ, Lee SS, Kim YJ, Park BD, Choi JS, Liu L, Ham YM, Moon Kim B, Lee SK.

Cancer Lett. 2010 Jan 28;287(2):196-206. doi: 10.1016/j.canlet.2009.06.011. Epub 2009 Jul 17.


Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.

Cai X, Hu X, Cai B, Wang Q, Li Y, Tan X, Hu H, Chen X, Huang J, Cheng J, Jing X.

Oncol Rep. 2013 Nov;30(5):2449-57. doi: 10.3892/or.2013.2718. Epub 2013 Sep 4.


Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells.

Eguchi H, Nagano H, Yamamoto H, Miyamoto A, Kondo M, Dono K, Nakamori S, Umeshita K, Sakon M, Monden M.

Clin Cancer Res. 2000 Jul;6(7):2881-90.


Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells.

Markovits J, Wang Z, Carr BI, Sun TP, Mintz P, Le Bret M, Wu CW, Wu FY.

Life Sci. 2003 May 2;72(24):2769-84.


Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C.

Cancer Res. 2006 Dec 15;66(24):11851-8.


Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo.

Yu J, Qiao L, Zimmermann L, Ebert MP, Zhang H, Lin W, Röcken C, Malfertheiner P, Farrell GC.

Hepatology. 2006 Jan;43(1):134-43.


In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.

DePinto W, Chu XJ, Yin X, Smith M, Packman K, Goelzer P, Lovey A, Chen Y, Qian H, Hamid R, Xiang Q, Tovar C, Blain R, Nevins T, Higgins B, Luistro L, Kolinsky K, Felix B, Hussain S, Heimbrook D.

Mol Cancer Ther. 2006 Nov;5(11):2644-58.


Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ.

Cancer Res. 1996 Jul 1;56(13):2973-8.


Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines.

Masuda M, Shimomura M, Kobayashi K, Kojima S, Nakatsura T.

Oncol Rep. 2011 Nov;26(5):1273-9. doi: 10.3892/or.2011.1370. Epub 2011 Jul 1.


Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis.

Tsai SL, Suk FM, Wang CI, Liu DZ, Hou WC, Lin PJ, Hung LF, Liang YC.

Biochem Pharmacol. 2007 Dec 3;74(11):1575-86. Epub 2007 Aug 11.


Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.

Ozaki I, Zhang H, Mizuta T, Ide Y, Eguchi Y, Yasutake T, Sakamaki T, Pestell RG, Yamamoto K.

Clin Cancer Res. 2007 Apr 1;13(7):2236-45.


Downregulation of p21(waf/cip-1) mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma.

Detjen KM, Murphy D, Welzel M, Farwig K, Wiedenmann B, Rosewicz S.

Exp Cell Res. 2003 Jan 15;282(2):78-89.


Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.

Qi R, An H, Yu Y, Zhang M, Liu S, Xu H, Guo Z, Cheng T, Cao X.

Cancer Res. 2003 Dec 1;63(23):8323-9.

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