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A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.

Raja SM, Metkar SS, Höning S, Wang B, Russin WA, Pipalia NH, Menaa C, Belting M, Cao X, Dressel R, Froelich CJ.

J Biol Chem. 2005 May 27;280(21):20752-61. Epub 2005 Mar 23.


Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage.

Grujic M, Braga T, Lukinius A, Eloranta ML, Knight SD, Pejler G, Abrink M.

J Biol Chem. 2005 Sep 30;280(39):33411-8. Epub 2005 Jul 26.


Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.

Dressel R, Raja SM, Höning S, Seidler T, Froelich CJ, von Figura K, Günther E.

J Biol Chem. 2004 May 7;279(19):20200-10. Epub 2004 Feb 25.


The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.

Veugelers K, Motyka B, Frantz C, Shostak I, Sawchuk T, Bleackley RC.

Blood. 2004 May 15;103(10):3845-53. Epub 2004 Jan 22.


Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.

Veugelers K, Motyka B, Goping IS, Shostak I, Sawchuk T, Bleackley RC.

Mol Biol Cell. 2006 Feb;17(2):623-33. Epub 2005 Nov 9.


Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.

Galvin JP, Spaeny-Dekking LH, Wang B, Seth P, Hack CE, Froelich CJ.

J Immunol. 1999 May 1;162(9):5345-50.


Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.

Gross C, Koelch W, DeMaio A, Arispe N, Multhoff G.

J Biol Chem. 2003 Oct 17;278(42):41173-81. Epub 2003 Jul 21.


Nuclear translocation of granzyme B in target cell apoptosis.

Pinkoski MJ, Heibein JA, Barry M, Bleackley RC.

Cell Death Differ. 2000 Jan;7(1):17-24.


Serglycin--structure and biology.

Kolset SO, Tveit H.

Cell Mol Life Sci. 2008 Apr;65(7-8):1073-85. Review.


Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling.

Sattar R, Ali SA, Abbasi A.

Biochem Biophys Res Commun. 2003 Sep 5;308(4):726-35.


Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

Raja SM, Wang B, Dantuluri M, Desai UR, Demeler B, Spiegel K, Metkar SS, Froelich CJ.

J Biol Chem. 2002 Dec 20;277(51):49523-30. Epub 2002 Oct 17.


Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1.

Davis JE, Sutton VR, Smyth MJ, Trapani JA.

Cell Death Differ. 2000 Oct;7(10):973-83.


Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.

Bird CH, Sun J, Ung K, Karambalis D, Whisstock JC, Trapani JA, Bird PI.

Mol Cell Biol. 2005 Sep;25(17):7854-67.


Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

Sutton VR, Brennan AJ, Ellis S, Danne J, Thia K, Jenkins MR, Voskoboinik I, Pejler G, Johnstone RW, Andrews DM, Trapani JA.

FEBS J. 2016 Mar;283(5):947-61. doi: 10.1111/febs.13649. Epub 2016 Jan 22.


Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Trapani JA.

Immunol Cell Biol. 2006 Feb;84(1):72-8. Review.


The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.

Adrain C, Duriez PJ, Brumatti G, Delivani P, Martin SJ.

J Biol Chem. 2006 Mar 24;281(12):8118-25. Epub 2006 Jan 16.


Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin.

Grujic M, Christensen JP, Sørensen MR, Abrink M, Pejler G, Thomsen AR.

J Immunol. 2008 Jul 15;181(2):1043-51.


New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.

Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W.

J Biol Chem. 1996 Nov 15;271(46):29073-9.


Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis.

Goping IS, Sawchuk T, Underhill DA, Bleackley RC.

J Cell Sci. 2006 Mar 1;119(Pt 5):858-65.

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