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Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.

Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, Greenwald R, Agger EM, Aagaard C, Weiler H, van Soolingen D, Dalemans W, Thomas AW, Andersen P.

Vaccine. 2005 Apr 15;23(21):2740-50.


Alteration of epitope recognition pattern in Ag85B and ESAT-6 has a profound influence on vaccine-induced protection against Mycobacterium tuberculosis.

Bennekov T, Dietrich J, Rosenkrands I, Stryhn A, Doherty TM, Andersen P.

Eur J Immunol. 2006 Dec;36(12):3346-55.


[Novel vaccines against M. tuberculosis].

Okada M.

Kekkaku. 2006 Dec;81(12):745-51. Review. Japanese.


Fusion protein Ag85B-MPT64(190-198)-Mtb8.4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium tuberculosis in mice.

Luo Y, Wang B, Hu L, Yu H, Da Z, Jiang W, Song N, Qie Y, Wang H, Tang Z, Xian Q, Zhang Y, Zhu B.

Vaccine. 2009 Oct 19;27(44):6179-85. doi: 10.1016/j.vaccine.2009.08.018. Epub 2009 Aug 25.


Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice.

Xu Y, Zhu B, Wang Q, Chen J, Qie Y, Wang J, Wang H, Wang B, Wang H.

FEMS Immunol Med Microbiol. 2007 Dec;51(3):480-7. Epub 2007 Oct 4.


Chimaeric protein improved immunogenicity compared with fusion protein of Ag85B and ESAT-6 antigens of Mycobacterium tuberculosis.

Xu Y, Wang B, Chen J, Wang Q, Zhu B, Shen H, Qie Y, Wang J, Wang H.

Scand J Immunol. 2006 Nov;64(5):476-81.


Immunogenicity and protective efficacy of a fusion protein vaccine consisting of antigen Ag85B and HspX against Mycobacterium tuberculosis infection in mice.

Li Q, Yu H, Zhang Y, Wang B, Jiang W, Da Z, Xian Q, Wang Y, Liu X, Zhu B.

Scand J Immunol. 2011 Jun;73(6):568-76. doi: 10.1111/j.1365-3083.2011.02531.x.


Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity.

Dietrich J, Andersen C, Rappuoli R, Doherty TM, Jensen CG, Andersen P.

J Immunol. 2006 Nov 1;177(9):6353-60.


The development and preliminary evaluation of a new Mycobacterium tuberculosis vaccine comprising Ag85b, HspX and CFP-10:ESAT-6 fusion protein with CpG DNA and aluminum hydroxide adjuvants.

Chen L, Xu M, Wang ZY, Chen BW, Du WX, Su C, Shen XB, Zhao AH, Dong N, Wang YJ, Wang GZ.

FEMS Immunol Med Microbiol. 2010 Jun 1;59(1):42-52. doi: 10.1111/j.1574-695X.2010.00660.x. Epub 2010 Feb 17.


Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis.

Tang C, Yamada H, Shibata K, Maeda N, Yoshida S, Wajjwalku W, Ohara N, Yamada T, Kinoshita T, Yoshikai Y.

J Infect Dis. 2008 May 1;197(9):1263-74. doi: 10.1086/586902.


Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model.

Olsen AW, Williams A, Okkels LM, Hatch G, Andersen P.

Infect Immun. 2004 Oct;72(10):6148-50.


An attenuated Salmonella-vectored vaccine elicits protective immunity against Mycobacterium tuberculosis.

Wang QL, Pan Q, Ma Y, Wang K, Sun P, Liu S, Zhang XL.

Vaccine. 2009 Nov 12;27(48):6712-22. doi: 10.1016/j.vaccine.2009.08.096. Epub 2009 Sep 4.


The Ag85B protein of Mycobacterium tuberculosis may turn a protective immune response induced by Ag85B-DNA vaccine into a potent but non-protective Th1 immune response in mice.

Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Orefici G, Fattorini L, Cassone A.

Cell Microbiol. 2007 Jun;9(6):1455-65. Epub 2007 Jan 22.


A novel DNA vaccine for protective immunity against virulent Mycobacterium bovis in mice.

Liu S, Gong Q, Wang C, Liu H, Wang Y, Guo S, Wang W, Liu J, Shao M, Chi L, Zhao K, Wang Z, Shi Y, Huang Y, Guli A, Zhang C, Kong X.

Immunol Lett. 2008 May 15;117(2):136-45. doi: 10.1016/j.imlet.2008.01.008. Epub 2008 Feb 12.


The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.

Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A.

Vaccine. 2008 Aug 5;26(33):4237-43. doi: 10.1016/j.vaccine.2008.05.050. Epub 2008 Jun 12.


Chitosan microspheres enhance the immunogenicity of an Ag85B-based fusion protein containing multiple T-cell epitopes of Mycobacterium tuberculosis.

Zhu Bd, Qie Yq, Wang Jl, Zhang Y, Wang Qz, Xu Y, Wang Hh.

Eur J Pharm Biopharm. 2007 Jun;66(3):318-26. Epub 2007 Jan 12.


Bacterial polyester inclusions engineered to display vaccine candidate antigens for use as a novel class of safe and efficient vaccine delivery agents.

Parlane NA, Wedlock DN, Buddle BM, Rehm BH.

Appl Environ Microbiol. 2009 Dec;75(24):7739-44. doi: 10.1128/AEM.01965-09. Epub 2009 Oct 16.


Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells.

Badell E, Nicolle F, Clark S, Majlessi L, Boudou F, Martino A, Castello-Branco L, Leclerc C, Lewis DJ, Marsh PD, Gicquel B, Winter N.

Vaccine. 2009 Jan 1;27(1):28-37. doi: 10.1016/j.vaccine.2008.10.034. Epub 2008 Oct 31.


A tuberculosis vaccine based on phosphoantigens and fusion proteins induces distinct gammadelta and alphabeta T cell responses in primates.

Cendron D, Ingoure S, Martino A, Casetti R, Horand F, Romagné F, Sicard H, Fournié JJ, Poccia F.

Eur J Immunol. 2007 Feb;37(2):549-65.

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