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Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW.

Science. 2005 Mar 18;307(5716):1776-8.


The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function.

Rudell JB, Rechs AJ, Kelman TJ, Ross-Inta CM, Hao S, Gietzen DW.

J Neurosci. 2011 Feb 2;31(5):1583-90. doi: 10.1523/JNEUROSCI.4934-10.2011.


Effects of essential amino acid deficiency: down-regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex.

Sharp JW, Ross-Inta CM, Baccelli I, Payne JA, Rudell JB, Gietzen DW.

J Neurochem. 2013 Nov;127(4):520-30. doi: 10.1111/jnc.12403. Epub 2013 Sep 12.


Mechanisms of food intake repression in indispensable amino acid deficiency.

Gietzen DW, Hao S, Anthony TG.

Annu Rev Nutr. 2007;27:63-78. Review.


The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.

Hao S, Ross-Inta CM, Gietzen DW.

Pharmacol Biochem Behav. 2010 Jan;94(3):333-40. doi: 10.1016/j.pbb.2009.09.014. Epub 2009 Oct 1.


The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.

Gietzen DW, Aja SM.

Mol Neurobiol. 2012 Oct;46(2):332-48. doi: 10.1007/s12035-012-8283-8. Epub 2012 Jun 7. Review.


Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC.

J Biol Chem. 2004 Aug 27;279(35):36553-61. Epub 2004 Jun 22.


Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p.

Zaborske JM, Narasimhan J, Jiang L, Wek SA, Dittmar KA, Freimoser F, Pan T, Wek RC.

J Biol Chem. 2009 Sep 11;284(37):25254-67. doi: 10.1074/jbc.M109.000877. Epub 2009 Jun 22.


Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

Kubota H, Obata T, Ota K, Sasaki T, Ito T.

J Biol Chem. 2003 Jun 6;278(23):20457-60. Epub 2003 Apr 2.


Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

Garcia-Barrio M, Dong J, Cherkasova VA, Zhang X, Zhang F, Ufano S, Lai R, Qin J, Hinnebusch AG.

J Biol Chem. 2002 Aug 23;277(34):30675-83. Epub 2002 Jun 17.


[Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway].

Fafournoux P, Averous J, Bruhat A, Carraro V, Jousse C, Maurin AC, Mesclon F, Parry L.

Biol Aujourdhui. 2015;209(4):317-23. doi: 10.1051/jbio/2016005. Epub 2016 Mar 28. Review. French.


Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae.

Zaborske JM, Wu X, Wek RC, Pan T.

BMC Biochem. 2010 Aug 4;11:29. doi: 10.1186/1471-2091-11-29.


Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices.

Appuhamy JA, Knoebel NA, Nayananjalie WA, Escobar J, Hanigan MD.

J Nutr. 2012 Mar;142(3):484-91. doi: 10.3945/jn.111.152595. Epub 2012 Feb 1.


The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.

Maurin AC, Jousse C, Averous J, Parry L, Bruhat A, Cherasse Y, Zeng H, Zhang Y, Harding HP, Ron D, Fafournoux P.

Cell Metab. 2005 Apr;1(4):273-7.


Hypothalamic eIF2α signaling regulates food intake.

Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B'chir W, Muranishi Y, Ron D, Pénicaud L, Fafournoux P.

Cell Rep. 2014 Feb 13;6(3):438-44. doi: 10.1016/j.celrep.2014.01.006. Epub 2014 Jan 30.


Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism.

Leib DE, Knight ZA.

Cell Rep. 2015 Nov 10;13(6):1081-1089. doi: 10.1016/j.celrep.2015.09.055. Epub 2015 Oct 29.

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