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Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver.

Mulligan JD, Gonzalez AA, Kumar R, Davis AJ, Saupe KW.

J Gerontol A Biol Sci Med Sci. 2005 Jan;60(1):21-7.


Effects of aging on cardiac and skeletal muscle AMPK activity: basal activity, allosteric activation, and response to in vivo hypoxemia in mice.

Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Saupe KW.

Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1270-5. Epub 2004 Jul 29.


Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H.

FASEB J. 2005 Jul;19(9):1146-8. Epub 2005 May 5.


α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, Tanaka S, Masuzaki H, Ebihara K, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Otaka A, Fushiki T, Nakao K.

Metabolism. 2006 Mar;55(3):300-8.


Hypoxia and AMP independently regulate AMP-activated protein kinase activity in heart.

Frederich M, Zhang L, Balschi JA.

Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2412-21. Epub 2005 Jan 6.


Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver.

Takekoshi K, Fukuhara M, Quin Z, Nissato S, Isobe K, Kawakami Y, Ohmori H.

Metabolism. 2006 Aug;55(8):1122-8.


Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity.

Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Weindruch R, Saupe KW.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1032-7. Epub 2004 Jul 13.


5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.

Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B.

Mol Cell Biol. 2006 Jul;26(14):5336-47.


Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.

Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):580-5.


Hypoxia, AMPK activation and uterine artery vasoreactivity.

Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG.

J Physiol. 2016 Mar 1;594(5):1357-69. doi: 10.1113/JP270995. Epub 2015 Jul 31.


Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K.

J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.


The regulation of AMP-activated protein kinase by H(2)O(2).

Choi SL, Kim SJ, Lee KT, Kim J, Mu J, Birnbaum MJ, Soo Kim S, Ha J.

Biochem Biophys Res Commun. 2001 Sep 14;287(1):92-7.


Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.

Ratchford AM, Chang AS, Chi MM, Sheridan R, Moley KH.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1198-206. Epub 2007 Aug 7.


Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart.

Zhang L, Frederich M, He H, Balschi JA.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1235-43. Epub 2005 Oct 28.


Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase.

Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, Tian R.

J Biol Chem. 2003 Aug 1;278(31):28372-7. Epub 2003 May 23.


Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Jørgensen SB, Viollet B, Andreelli F, Frøsig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF.

J Biol Chem. 2004 Jan 9;279(2):1070-9. Epub 2003 Oct 21.


Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.

Viana AY, Sakoda H, Anai M, Fujishiro M, Ono H, Kushiyama A, Fukushima Y, Sato Y, Oshida Y, Uchijima Y, Kurihara H, Asano T.

Diabetes Res Clin Pract. 2006 Aug;73(2):135-42. Epub 2006 Feb 28.


Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice.

Yang J, Maika S, Craddock L, King JA, Liu ZM.

Biochem Biophys Res Commun. 2008 May 30;370(2):248-53. doi: 10.1016/j.bbrc.2008.03.094. Epub 2008 Mar 31.


AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG.

Biochem J. 1998 Aug 15;334 ( Pt 1):177-87.

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