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Items: 1 to 20 of 132

1.

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.

Wang XJ, Chamberlain M, Vassieva O, Henderson CJ, Wolf CR.

Biochem J. 2005 Jun 15;388(Pt 3):857-67.

3.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR.

J Biol Chem. 2003 Apr 11;278(15):13480-6. Epub 2003 Feb 3.

4.

The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism.

Mutch DM, Klocke B, Morrison P, Murray CA, Henderson CJ, Seifert M, Williamson G.

J Proteome Res. 2007 Oct;6(10):3976-84. Epub 2007 Aug 28.

PMID:
17722906
5.

Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.

Cheng X, Zhang Y, Klaassen CD.

J Pharmacol Exp Ther. 2014 Oct;351(1):105-13. doi: 10.1124/jpet.114.216796. Epub 2014 Jul 17.

6.

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity.

Henderson CJ, Pass GJ, Wolf CR.

Toxicol Lett. 2006 Mar 15;162(1):111-7. Epub 2005 Dec 15.

PMID:
16343823
7.

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450.

Wu L, Gu J, Cui H, Zhang QY, Behr M, Fang C, Weng Y, Kluetzman K, Swiatek PJ, Yang W, Kaminsky L, Ding X.

J Pharmacol Exp Ther. 2005 Jan;312(1):35-43. Epub 2004 Aug 24.

8.

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse.

Pass GJ, Carrie D, Boylan M, Lorimore S, Wright E, Houston B, Henderson CJ, Wolf CR.

Cancer Res. 2005 May 15;65(10):4211-7.

9.

Suppression of cytochrome P450 reductase (POR) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR-null mice.

Porter TD, Banerjee S, Stolarczyk EI, Zou L.

Drug Metab Dispos. 2011 Jun;39(6):966-73. doi: 10.1124/dmd.111.038562. Epub 2011 Mar 2.

10.

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Arlt VM, Stiborová M, Henderson CJ, Thiemann M, Frei E, Aimová D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH.

Carcinogenesis. 2008 Mar;29(3):656-65. doi: 10.1093/carcin/bgn002. Epub 2008 Jan 19.

PMID:
18204078
11.

The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene.

Lee C, Ding X, Riddick DS.

Drug Metab Dispos. 2013 Feb;41(2):457-65. doi: 10.1124/dmd.112.048835. Epub 2012 Nov 20.

13.

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase.

Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, Ding X.

J Biol Chem. 2003 Jul 11;278(28):25895-901. Epub 2003 Apr 15.

14.

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Kotrbová V, Moserová M, Hudecek J, Phillips DH, Frei E.

Toxicol Appl Pharmacol. 2008 Feb 1;226(3):318-27. Epub 2007 Sep 26.

PMID:
17976674
15.
16.

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

Mutch DM, Crespy V, Clough J, Henderson CJ, Lariani S, Mansourian R, Moulin J, Wolf CR, Williamson G.

Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G63-72. Epub 2006 Feb 2.

17.

Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis.

Otto DM, Henderson CJ, Carrie D, Davey M, Gundersen TE, Blomhoff R, Adams RH, Tickle C, Wolf CR.

Mol Cell Biol. 2003 Sep;23(17):6103-16.

18.

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

Finn RD, Henderson CJ, Scott CL, Wolf CR.

Biochem J. 2009 Jan 1;417(1):43-54. doi: 10.1042/BJ20080740.

19.

Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes.

Cheng X, Gu J, Klaassen CD.

Drug Metab Dispos. 2014 Nov;42(11):1826-33. doi: 10.1124/dmd.114.060053. Epub 2014 Aug 21.

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