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Items: 1 to 20 of 94

1.

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

Allerson CR, Sioufi N, Jarres R, Prakash TP, Naik N, Berdeja A, Wanders L, Griffey RH, Swayze EE, Bhat B.

J Med Chem. 2005 Feb 24;48(4):901-4.

PMID:
15715458
2.

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.

Vickers TA, Koo S, Bennett CF, Crooke ST, Dean NM, Baker BF.

J Biol Chem. 2003 Feb 28;278(9):7108-18. Epub 2002 Dec 23.

3.

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells.

Czauderna F, Fechtner M, Dames S, Aygün H, Klippel A, Pronk GJ, Giese K, Kaufmann J.

Nucleic Acids Res. 2003 Jun 1;31(11):2705-16.

4.
5.

Synthesis of oligonucleotides carrying amino lipid groups at the 3'-end for RNA interference studies.

Grijalvo S, Ocampo SM, Perales JC, Eritja R.

J Org Chem. 2010 Oct 15;75(20):6806-13. doi: 10.1021/jo101143j.

PMID:
20863084
6.

Positional effect of chemical modifications on short interference RNA activity in mammalian cells.

Prakash TP, Allerson CR, Dande P, Vickers TA, Sioufi N, Jarres R, Baker BF, Swayze EE, Griffey RH, Bhat B.

J Med Chem. 2005 Jun 30;48(13):4247-53.

PMID:
15974578
7.

[PTEN--a new tumor inhibitory gene].

Tian X, Wu H.

Zhonghua Bing Li Xue Za Zhi. 2000 Dec;29(6):455-7. Review. Chinese. No abstract available.

PMID:
12790140
8.

Synthesis and in vitro inhibition properties of siRNA conjugates carrying acridine and quindoline moieties.

Aviñó A, Ocampo SM, Perales JC, Eritja R.

Chem Biodivers. 2012 Mar;9(3):557-66. doi: 10.1002/cbdv.201100321.

PMID:
22422523
9.

Transient strong reduction of PTEN expression by specific RNAi induces loss of adhesion of the cells.

Mise-Omata S, Obata Y, Iwase S, Mise N, Doi TS.

Biochem Biophys Res Commun. 2005 Mar 25;328(4):1034-42.

PMID:
15707982
10.

Sequence-specific inhibition of small RNA function.

Hutvágner G, Simard MJ, Mello CC, Zamore PD.

PLoS Biol. 2004 Apr;2(4):E98. Epub 2004 Feb 24.

11.

Insulin-like growth factor-II regulates PTEN expression in the mammary gland.

Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KL, Edwards DR, Khokha R.

J Biol Chem. 2003 Dec 12;278(50):50422-7. Epub 2003 Sep 29.

12.

Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA.

Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M.

Bioorg Med Chem. 2013 Feb 1;21(3):722-32. doi: 10.1016/j.bmc.2012.11.043. Epub 2012 Dec 3.

PMID:
23260577
13.
14.

Competition for RISC binding predicts in vitro potency of siRNA.

Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash TP, Allerson CR, Swayze EE, Marcusson EG, Dean NM.

Nucleic Acids Res. 2006;34(16):4467-76. Epub 2006 Aug 31.

15.

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

Czauderna F, Fechtner M, Aygün H, Arnold W, Klippel A, Giese K, Kaufmann J.

Nucleic Acids Res. 2003 Jan 15;31(2):670-82.

16.

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

Sun X, Rogoff HA, Li CJ.

Nat Biotechnol. 2008 Dec;26(12):1379-82. doi: 10.1038/nbt.1512. Epub 2008 Nov 23. Erratum in: Nat Biotechnol. 2009 Feb;27(2):205.

PMID:
19029911
17.

Deregulated Akt3 activity promotes development of malignant melanoma.

Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW, Kester M, Sandirasegarane L, Robertson GP.

Cancer Res. 2004 Oct 1;64(19):7002-10.

18.

Mutation analysis of the PTEN gene in uveal melanoma cell lines.

Naus NC, Zuidervaart W, Rayman N, Slater R, van Drunen E, Ksander B, Luyten GP, Klein A.

Int J Cancer. 2000 Jul 1;87(1):151-3. No abstract available.

19.

Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells.

Prakash TP, Naik N, Sioufi N, Bhat B, Swayze EE.

Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):902-10. doi: 10.1080/15257770903316145.

PMID:
20183560
20.

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.

Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ.

Nucleic Acids Res. 2010 Jul;38(13):4547-57. doi: 10.1093/nar/gkq181. Epub 2010 Apr 22.

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