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DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD.

J Biol Chem. 2005 Apr 15;280(15):15158-64. Epub 2005 Feb 15.


Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.

Jowsey PA, Doherty AJ, Rouse J.

J Biol Chem. 2004 Dec 31;279(53):55562-9. Epub 2004 Sep 27.


Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK.

J Biol Chem. 2005 Jul 29;280(30):27587-94. Epub 2005 Jun 1.


Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.

Mamon HJ, Dahlberg W, Azzam EI, Nagasawa H, Muto MG, Little JB.

Int J Radiat Biol. 2003 Oct;79(10):817-29.


Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK.

Cancer Res. 2000 Jun 15;60(12):3299-304.


BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.

Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK.

J Biol Chem. 2004 Jul 23;279(30):31251-8. Epub 2004 May 24.


ATM activation by ionizing radiation requires BRCA1-associated BAAT1.

Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T.

J Biol Chem. 2006 Apr 7;281(14):9710-8. Epub 2006 Feb 1.


Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.

Lou Z, Chini CC, Minter-Dykhouse K, Chen J.

J Biol Chem. 2003 Apr 18;278(16):13599-602. Epub 2003 Feb 27.


Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR.

Biochem J. 2002 Dec 1;368(Pt 2):507-16.


Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.

Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.

Mol Cell Biol. 2005 Jan;25(2):661-70.


The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.

Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T.

PLoS Biol. 2004 Aug;2(8):E240. Epub 2004 Aug 17.


ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.

Xue L, Yu D, Furusawa Y, Cao J, Okayasu R, Fan S.

Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):235-43. doi: 10.1016/j.ijrobp.2009.04.088.


Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS.

Mol Cancer Res. 2003 Jul;1(9):674-81.


Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

Stewart GS, Last JI, Stankovic T, Haites N, Kidd AM, Byrd PJ, Taylor AM.

J Biol Chem. 2001 Aug 10;276(32):30133-41. Epub 2001 May 29.


Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.

Int J Cancer. 2006 Feb 15;118(4):857-68.


Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.

Au WW, Henderson BR.

Cell Signal. 2007 Sep;19(9):1879-92. Epub 2007 May 1.


The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.


A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Sun Y, Jiang X, Chen S, Fernandes N, Price BD.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13182-7. Epub 2005 Sep 2.


Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.

So S, Davis AJ, Chen DJ.

J Cell Biol. 2009 Dec 28;187(7):977-90. doi: 10.1083/jcb.200906064. Epub 2009 Dec 21. Erratum in: J Cell Biol. 2010 Feb 8;188(3):443.


NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

Wilson KA, Stern DF.

Cell Cycle. 2008 Nov 15;7(22):3584-94. Epub 2008 Nov 29.

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