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Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.

Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM.

Nat Med. 2005 Mar;11(3):291-7. Epub 2005 Feb 13.


Biological effects of rAAV-caAlk2 coating on structural allograft healing.

Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM.

Mol Ther. 2005 Aug;12(2):212-8.


Recent advances in gene delivery for structural bone allografts.

Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM.

Tissue Eng. 2007 Aug;13(8):1973-85. Review.


Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.

Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA.

Mol Ther. 2008 Mar;16(3):466-73. doi: 10.1038/ Epub 2008 Jan 8.


The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.

Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM.

Biomaterials. 2008 Oct;29(28):3882-7. doi: 10.1016/j.biomaterials.2008.06.007. Epub 2008 Jun 30.


Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo.

Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH.

Biomaterials. 2006 Oct;27(30):5161-9. Epub 2006 Jun 30.


Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction.

Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA.

J Orthop Res. 2008 Jun;26(6):824-33. doi: 10.1002/jor.20531.


Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM.

Mol Ther. 2011 Aug;19(8):1416-25. doi: 10.1038/mt.2010.294. Epub 2011 Jan 4.


RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism.

Henriksen K, Karsdal M, Delaisse JM, Engsig MT.

J Biol Chem. 2003 Dec 5;278(49):48745-53. Epub 2003 Sep 23.


The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling.

Theoleyre S, Wittrant Y, Tat SK, Fortun Y, Redini F, Heymann D.

Cytokine Growth Factor Rev. 2004 Dec;15(6):457-75. Review.


[Osteoprotegrin and RANKL/RANK system: is it the future of bone metabolism?].

Ferrer Cañabate J, Tovar I, Martínez P.

An Med Interna. 2002 Aug;19(8):385-88. Review. Spanish. No abstract available.


The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection.

Guillonneau C, Louvet C, Renaudin K, Heslan JM, Heslan M, Tesson L, Vignes C, Guillot C, Choi Y, Turka LA, Cuturi MC, Anegon I, Josien R.

J Immunol. 2004 Feb 1;172(3):1619-29.


Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice.

Kodama I, Niida S, Sanada M, Yoshiko Y, Tsuda M, Maeda N, Ohama K.

J Bone Miner Res. 2004 Feb;19(2):200-6. Epub 2003 Dec 16.


Adeno-associated virus-coated allografts: a novel approach for cranioplasty.

Ben Arav A, Pelled G, Zilberman Y, Kimelman-Bleich N, Gazit Z, Schwarz EM, Gazit D.

J Tissue Eng Regen Med. 2012 Nov;6(10):e43-50. doi: 10.1002/term.1594. Epub 2012 Sep 3.


RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing.

Wilson SE, Mohan RR, Netto M, Perez V, Possin D, Huang J, Kwon R, Alekseev A, Rodriguez-Perez JP.

Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2201-11.


Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury.

Galeano M, Deodato B, Altavilla D, Squadrito G, Seminara P, Marini H, Stagno d'Alcontres F, Colonna M, Calò M, Lo Cascio P, Torre V, Giacca M, Venuti FS, Squadrito F.

Crit Care Med. 2003 Apr;31(4):1017-25.


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