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Items: 1 to 20 of 305

1.

AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

Kunsch C, Luchoomun J, Chen XL, Dodd GL, Karu KS, Meng CQ, Marino EM, Olliff LK, Piper JD, Qiu FH, Sikorski JA, Somers PK, Suen KL, Thomas S, Whalen AM, Wasserman MA, Sundell CL.

J Pharmacol Exp Ther. 2005 May;313(2):492-501.

2.

Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

Kunsch C, Luchoomun J, Grey JY, Olliff LK, Saint LB, Arrendale RF, Wasserman MA, Saxena U, Medford RM.

J Pharmacol Exp Ther. 2004 Mar;308(3):820-9.

3.

AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA, Alexander RW, Medford RM, Saxena U.

J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23.

4.

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Meng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDOnald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA.

J Med Chem. 2004 Dec 2;47(25):6420-32.

PMID:
15566311
6.

Inhibition of endothelial cell adhesion by the new anti-inflammatory agent alpha-iso-cubebene.

Choi YW, Kim HJ, Park SS, Chung JH, Lee HW, Oh SO, Kim BS, Kim JB, Chung HY, Yu BP, Kim CD, Yoon S.

Vascul Pharmacol. 2009 Oct;51(4):215-24. doi: 10.1016/j.vph.2009.05.008.

PMID:
19539051
7.

Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells.

Chang WC, Chen CH, Lee MF, Chang T, Yu YM.

Eur J Nutr. 2010 Aug;49(5):267-75. doi: 10.1007/s00394-009-0083-1.

PMID:
19937041
8.

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y.

J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001.

9.

Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.

Chen XL, Dodd G, Thomas S, Zhang X, Wasserman MA, Rovin BH, Kunsch C.

Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1862-70.

10.

Inhibitory effects of clotrimazole on TNF-alpha-induced adhesion molecule expression and angiogenesis.

Thapa D, Lee JS, Park MA, Cho MY, Park YJ, Choi HG, Jeong TC, Kim JA.

Arch Pharm Res. 2009 Apr;32(4):593-603. doi: 10.1007/s12272-009-1416-6.

PMID:
19407978
11.

Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.

Hung CF, Huang TF, Chen BH, Shieh JM, Wu PH, Wu WB.

Eur J Pharmacol. 2008 May 31;586(1-3):275-82. doi: 10.1016/j.ejphar.2008.03.001.

PMID:
18439578
12.

In vitro effects of 2 antirheumatic drugs on the synthesis and expression of proinflammatory cytokines in synovial membranes from patients with rheumatoid arthritis.

Ounissi-Benkalha H, Pelletier JP, Tardif G, Mineau F, Jolicoeur FC, Ranger P, Martel-Pelletier J.

J Rheumatol. 1996 Jan;23(1):16-23.

PMID:
8838503
13.

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.

Tran TA, McCoy MK, Sporn MB, Tansey MG.

J Neuroinflammation. 2008 May 12;5:14. doi: 10.1186/1742-2094-5-14.

14.
15.

Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.

Chen YH, Lin SJ, Chen YL, Liu PL, Chen JW.

Cardiovasc Hematol Disord Drug Targets. 2006 Dec;6(4):279-304. Review.

PMID:
17378773
16.

Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells.

Jiang MZ, Tsukahara H, Hayakawa K, Todoroki Y, Tamura S, Ohshima Y, Hiraoka M, Mayumi M.

Respir Med. 2005 May;99(5):580-91.

17.

4-O-methylgallic acid down-regulates endothelial adhesion molecule expression by inhibiting NF-kappaB-DNA-binding activity.

Lee G, Na HJ, Namkoong S, Jeong Kwon H, Han S, Ha KS, Kwon YG, Lee H, Kim YM.

Eur J Pharmacol. 2006 Dec 3;551(1-3):143-51.

PMID:
17027748
18.

Effects of AGI-1096, a novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis.

Murata S, Sundell CL, Lijkwan MA, Balsam LB, Hammainen P, Coleman C, York C, Luchoomun J, Suen KL, Howard R, Somers PK, Morris RE, Robbins RC.

Transplantation. 2004 May 27;77(10):1494-500.

PMID:
15239610
20.

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