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Items: 1 to 20 of 215

1.

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.

Zampieri N, Xu CF, Neubert TA, Chao MV.

J Biol Chem. 2005 Apr 15;280(15):14563-71. Epub 2005 Feb 8.

2.

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor.

Jung KM, Tan S, Landman N, Petrova K, Murray S, Lewis R, Kim PK, Kim DS, Ryu SH, Chao MV, Kim TW.

J Biol Chem. 2003 Oct 24;278(43):42161-9. Epub 2003 Aug 11.

3.

Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, Schecterson LC.

J Neurosci. 2003 Jul 2;23(13):5425-36.

4.

The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase.

Sykes AM, Palstra N, Abankwa D, Hill JM, Skeldal S, Matusica D, Venkatraman P, Hancock JF, Coulson EJ.

J Biol Chem. 2012 Dec 21;287(52):43810-24. doi: 10.1074/jbc.M112.382903. Epub 2012 Oct 26.

5.

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.

Gowrishankar K, Zeidler MG, Vincenz C.

J Cell Sci. 2004 Aug 15;117(Pt 18):4099-111. Epub 2004 Jul 27.

6.
7.

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R.

J Biol Chem. 2004 Dec 3;279(49):50864-73. Epub 2004 Sep 23.

8.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

9.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

10.

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.

Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ.

J Biol Chem. 2002 Apr 26;277(17):15069-75. Epub 2002 Feb 11.

11.

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

Lee HJ, Jung KM, Huang YZ, Bennett LB, Lee JS, Mei L, Kim TW.

J Biol Chem. 2002 Feb 22;277(8):6318-23. Epub 2001 Dec 10.

12.
13.

Nicastrin functions as a gamma-secretase-substrate receptor.

Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Südhof T, Yu G.

Cell. 2005 Aug 12;122(3):435-47.

14.

Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase.

Underwood CK, Reid K, May LM, Bartlett PF, Coulson EJ.

Mol Cell Neurosci. 2008 Feb;37(2):346-58. Epub 2007 Oct 23.

PMID:
18055214
15.

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain.

Urra S, Escudero CA, Ramos P, Lisbona F, Allende E, Covarrubias P, Parraguez JI, Zampieri N, Chao MV, Annaert W, Bronfman FC.

J Biol Chem. 2007 Mar 9;282(10):7606-15. Epub 2007 Jan 9.

16.

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS.

Biochemistry. 2003 Jan 14;42(1):137-44.

PMID:
12515548
17.

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

Zhao G, Mao G, Tan J, Dong Y, Cui MZ, Kim SH, Xu X.

J Biol Chem. 2004 Dec 3;279(49):50647-50. Epub 2004 Oct 13.

18.

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein.

Olry A, Chastagner P, Israël A, Brou C.

J Biol Chem. 2005 Aug 5;280(31):28564-71. Epub 2005 Jun 15.

19.
20.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

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