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Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin.

Min J, Traynor D, Stegner AL, Zhang L, Hanigan MH, Alexander H, Alexander S.

Eukaryot Cell. 2005 Jan;4(1):178-89.


(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.

Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Futerman AH, Alexander S.

Mol Cancer Res. 2007 Aug;5(8):801-12.


Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.

Min J, Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S.

Mol Cancer Res. 2005 May;3(5):287-96.


Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium.

Li G, Alexander H, Schneider N, Alexander S.

Microbiology. 2000 Sep;146 ( Pt 9):2219-27.


Global transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets.

Van Driessche N, Alexander H, Min J, Kuspa A, Alexander S, Shaulsky G.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15406-11.


Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.

Matula K, Collie-Duguid E, Murray G, Parikh K, Grabsch H, Tan P, Lalwani S, Garau R, Ong Y, Bain G, Smith AD, Urquhart G, Bielawski J, Finnegan M, Petty R.

BMC Cancer. 2015 Oct 22;15:762. doi: 10.1186/s12885-015-1718-7.


[Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].

Yin GJ, Lan KH, Hu CY, Lu Q, Tang W, Wang SF.

Zhonghua Zhong Liu Za Zhi. 2012 Feb;34(2):96-9. doi: 10.3760/cma.j.issn.0253-3766.2012.02.004. Chinese.


Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.

Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S.

J Biol Chem. 2000 Jun 30;275(26):19513-20.


Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.

Hara-Yokoyama M, Terasawa K, Ichinose S, Watanabe A, Podyma-Inoue KA, Akiyoshi K, Igarashi Y, Yanagishita M.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2220-4. doi: 10.1016/j.bmcl.2013.01.083.


FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression.

Ishitsuka A, Fujine E, Mizutani Y, Tawada C, Kanoh H, Banno Y, Seishima M.

Int J Mol Med. 2014 Oct;34(4):1169-74. doi: 10.3892/ijmm.2014.1882.


Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis.

Kumar A, Wessels D, Daniels KJ, Alexander H, Alexander S, Soll DR.

Cell Motil Cytoskeleton. 2004 Dec;59(4):227-41.


Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.

Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marfè G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R.

Clin Cancer Res. 2013 Jan 1;19(1):138-47. doi: 10.1158/1078-0432.CCR-12-1050.


Molecular cloning and functional characterization of murine sphingosine kinase.

Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S.

J Biol Chem. 1998 Sep 11;273(37):23722-8.


Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.

Li G, Foote C, Alexander S, Alexander H.

Development. 2001 Sep;128(18):3473-83.


Pharmacogenetics of resistance to Cisplatin and other anticancer drugs and the role of sphingolipid metabolism.

Alexander S, Swatson WS, Alexander H.

Methods Mol Biol. 2013;983:185-204. doi: 10.1007/978-1-62703-302-2_10.


Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase.

Ibrahim FB, Pang SJ, Melendez AJ.

J Biol Chem. 2004 Oct 22;279(43):44802-11.


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