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Items: 1 to 20 of 155

1.

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54. Epub 2005 Jan 7.

2.

Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue.

Horiguchi K, Yamada M, Satoh T, Hashimoto K, Hirato J, Tosaka M, Yamada S, Mori M.

Clin Cancer Res. 2009 Apr 15;15(8):2620-9. doi: 10.1158/1078-0432.CCR-08-2473. Epub 2009 Mar 24.

3.

Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs.

Taguchi R, Yamada M, Horiguchi K, Tomaru T, Ozawa A, Shibusawa N, Hashimoto K, Okada S, Satoh T, Mori M.

Biochem Biophys Res Commun. 2011 Nov 18;415(2):378-83. doi: 10.1016/j.bbrc.2011.10.077. Epub 2011 Oct 21.

PMID:
22037578
4.

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c.

Karnik SK, Hughes CM, Gu X, Rozenblatt-Rosen O, McLean GW, Xiong Y, Meyerson M, Kim SK.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14659-64. Epub 2005 Sep 29.

5.

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.

Dreijerink KM, Höppener JW, Timmers HM, Lips CJ.

Nat Clin Pract Endocrinol Metab. 2006 Oct;2(10):562-70. Review.

PMID:
17024155
6.

Mechanisms of transformation by MLL.

Hess JL.

Crit Rev Eukaryot Gene Expr. 2004;14(4):235-54. Review.

PMID:
15663355
7.

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

Yokoyama A, Somervaille TC, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML.

Cell. 2005 Oct 21;123(2):207-18.

8.

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS.

PLoS Genet. 2006 Apr;2(4):e51. Epub 2006 Apr 7.

9.

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML.

Mol Cell Biol. 2004 Jul;24(13):5639-49.

12.

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH.

Mol Cell Biol. 2002 Nov;22(22):7842-52.

13.

Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway.

Cheng P, Wang YF, Li G, Yang SS, Liu C, Hu H, Jin G, Hu XG.

Cancer Lett. 2016 Jan 1;370(1):136-44. doi: 10.1016/j.canlet.2015.09.019. Epub 2015 Oct 8.

PMID:
26454216
14.
16.

Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia.

Scott SA, Kimura T, Dong WF, Ichinohasama R, Bergen S, Kerviche A, Sheridan D, DeCoteau JF.

Leuk Res. 2004 Dec;28(12):1293-301.

PMID:
15475071
17.

p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression.

Zerfass-Thome K, Schulze A, Zwerschke W, Vogt B, Helin K, Bartek J, Henglein B, Jansen-Dürr P.

Mol Cell Biol. 1997 Jan;17(1):407-15.

18.

p27Kip1 induces an accumulation of the repressor complexes of E2F and inhibits expression of the E2F-regulated genes.

Shiyanov P, Hayes S, Chen N, Pestov DG, Lau LF, Raychaudhuri P.

Mol Biol Cell. 1997 Sep;8(9):1815-27.

19.

Genetic evidence for functional dependency of p18Ink4c on Cdk4.

Pei XH, Bai F, Tsutsui T, Kiyokawa H, Xiong Y.

Mol Cell Biol. 2004 Aug;24(15):6653-64.

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