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Items: 1 to 20 of 162


Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J.

J Virol. 2004 Oct;78(19):10636-49.


Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.

Solis M, Romieu-Mourez R, Goubau D, Grandvaux N, Mesplede T, Julkunen I, Nardin A, Salcedo M, Hiscott J.

Eur J Immunol. 2007 Feb;37(2):528-39.


Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.

Hammaker D, Boyle DL, Firestein GS.

Rheumatology (Oxford). 2012 Apr;51(4):610-8. doi: 10.1093/rheumatology/ker154. Epub 2011 May 25.


Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB.

J Biol Chem. 2004 Apr 9;279(15):15652-61. Epub 2004 Jan 22.


Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J.

J Biol Chem. 2003 Mar 14;278(11):9441-7. Epub 2003 Jan 10.


Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.


The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.

J Exp Med. 2004 Jun 21;199(12):1641-50.


The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.

Clark K, Takeuchi O, Akira S, Cohen P.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17093-8. doi: 10.1073/pnas.1114194108. Epub 2011 Sep 23.


Triggering the interferon antiviral response through an IKK-related pathway.

Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J.

Science. 2003 May 16;300(5622):1148-51. Epub 2003 Apr 17.


Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.

Civas A, Génin P, Morin P, Lin R, Hiscott J.

J Biol Chem. 2006 Feb 24;281(8):4856-66. Epub 2005 Dec 27.


Targeting the NF-kappaB pathway through pharmacological inhibition of IKK2 prevents human cytomegalovirus replication and virus-induced inflammatory response in infected endothelial cells.

Caposio P, Musso T, Luganini A, Inoue H, Gariglio M, Landolfo S, Gribaudo G.

Antiviral Res. 2007 Mar;73(3):175-84. Epub 2006 Oct 23.


IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.

McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):233-8. Epub 2003 Dec 16.


IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.

Sankar S, Chan H, Romanow WJ, Li J, Bates RJ.

Cell Signal. 2006 Jul;18(7):982-93. Epub 2005 Sep 30.


Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.

Minisini R, Tulone C, Lüske A, Michel D, Mertens T, Gierschik P, Moepps B.

J Virol. 2003 Apr;77(8):4489-501.


Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.

Paz S, Sun Q, Nakhaei P, Romieu-Mourez R, Goubau D, Julkunen I, Lin R, Hiscott J.

Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):17-28.


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