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Items: 1 to 20 of 78


Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma.

Voigt P, Brock C, Nürnberg B, Schaefer M.

J Biol Chem. 2005 Feb 11;280(6):5121-7. Epub 2004 Dec 20.


The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

Shymanets A, Ahmadian MR, Kössmeier KT, Wetzker R, Harteneck C, Nürnberg B.

Biochem J. 2012 Feb 1;441(3):851-8. doi: 10.1042/BJ20111664.


Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.

Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B.

J Cell Biol. 2003 Jan 6;160(1):89-99. Epub 2002 Dec 30.


Differential sensitivity of phosphatidylinositol 3-kinase p110gamma to isoforms of G protein betagamma dimers.

Kerchner KR, Clay RL, McCleery G, Watson N, McIntire WE, Myung CS, Garrison JC.

J Biol Chem. 2004 Oct 22;279(43):44554-62. Epub 2004 Aug 18.


Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B.

Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099.


Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

Leopoldt D, Hanck T, Exner T, Maier U, Wetzker R, Nürnberg B.

J Biol Chem. 1998 Mar 20;273(12):7024-9.


Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival.

Johnson C, Marriott SJ, Levy LS.

Oncogene. 2007 Oct 25;26(49):7049-57. Epub 2007 May 7.


PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

Bohnacker T, Marone R, Collmann E, Calvez R, Hirsch E, Wymann MP.

Sci Signal. 2009 Jun 9;2(74):ra27. doi: 10.1126/scisignal.2000259.


Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.

Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. doi: 10.1073/pnas.0905506106. Epub 2009 Nov 11.


Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.


p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.

Shymanets A, Prajwal, Bucher K, Beer-Hammer S, Harteneck C, Nürnberg B.

J Biol Chem. 2013 Oct 25;288(43):31059-68. doi: 10.1074/jbc.M113.508234. Epub 2013 Sep 6.


Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.

Bonacci TM, Ghosh M, Malik S, Smrcka AV.

J Biol Chem. 2005 Mar 18;280(11):10174-81. Epub 2004 Dec 16.


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