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Items: 1 to 20 of 101

1.

Endotoxin recognition and signal transduction by the TLR4/MD2-complex.

Fitzgerald KA, Rowe DC, Golenbock DT.

Microbes Infect. 2004 Dec;6(15):1361-7. Review.

PMID:
15596121
2.

Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling.

Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M, Himi T, Miyake K, Kuroki Y.

J Immunol. 2004 Dec 1;173(11):6949-54.

3.

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.

Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT.

J Biol Chem. 2003 Nov 28;278(48):48313-20. Epub 2003 Sep 5.

4.

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.

Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT.

J Exp Med. 2001 Jul 2;194(1):79-88.

5.

Endotoxin recognition molecules, Toll-like receptor 4-MD-2.

Miyake K.

Semin Immunol. 2004 Feb;16(1):11-6. Review.

PMID:
14751758
6.

Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling.

Saitoh S, Akashi S, Yamada T, Tanimura N, Matsumoto F, Fukase K, Kusumoto S, Kosugi A, Miyake K.

J Endotoxin Res. 2004;10(4):257-60.

PMID:
15373971
7.

LPS, TLR4 and infectious disease diversity.

Miller SI, Ernst RK, Bader MW.

Nat Rev Microbiol. 2005 Jan;3(1):36-46. Review.

PMID:
15608698
8.

MD-2: the Toll 'gatekeeper' in endotoxin signalling.

Gangloff M, Gay NJ.

Trends Biochem Sci. 2004 Jun;29(6):294-300.

PMID:
15276183
9.

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.

Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, Miyake K.

J Immunol. 2000 Apr 1;164(7):3471-5.

10.
11.

Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS.

Dueñas AI, Orduña A, Crespo MS, García-Rodríguez C.

Int Immunol. 2004 Oct;16(10):1467-75. Epub 2004 Aug 31.

PMID:
15339879
12.

MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.

da Silva Correia J, Ulevitch RJ.

J Biol Chem. 2002 Jan 18;277(3):1845-54. Epub 2001 Nov 12.

13.

Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2.

Miyake K.

Trends Microbiol. 2004 Apr;12(4):186-92. Review.

PMID:
15051069
15.

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.

Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T.

J Biol Chem. 2002 Dec 6;277(49):47834-43. Epub 2002 Sep 24.

17.

Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses.

Triantafilou M, Brandenburg K, Kusumoto S, Fukase K, Mackie A, Seydel U, Triantafilou K.

Biochem J. 2004 Jul 15;381(Pt 2):527-36.

18.

Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling.

Fichorova RN, Cronin AO, Lien E, Anderson DJ, Ingalls RR.

J Immunol. 2002 Mar 1;168(5):2424-32.

19.

[The role of myeloid differential protein-2 in innate immunity].

Xu FL, Li L.

Sheng Li Ke Xue Jin Zhan. 2004 Apr;35(2):139-42. Review. Chinese.

PMID:
15285420
20.

The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface.

Fujimoto T, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T.

J Biol Chem. 2004 Nov 12;279(46):47431-7. Epub 2004 Aug 26.

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