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Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.

Lee YC, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, Nesbitt JC, Chambers RC, Thompson PJ, Light RW.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L734-40. Epub 2004 Dec 10.


Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms.

Nishikawa H, Kawai K, Tanaka M, Ohtani H, Tanaka S, Kitagawa C, Nishida M, Abe T, Araki H, Kawabata A.

J Pharmacol Exp Ther. 2005 Jan;312(1):324-31. Epub 2004 Aug 26.


Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways.

Ebeling C, Forsythe P, Ng J, Gordon JR, Hollenberg M, Vliagoftis H.

J Allergy Clin Immunol. 2005 Mar;115(3):623-30.


Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase.

Compton SJ, Renaux B, Wijesuriya SJ, Hollenberg MD.

Br J Pharmacol. 2001 Oct;134(4):705-18.


Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin.

Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD.

J Pharmacol Exp Ther. 2002 Feb;300(2):702-8.


PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium.

Rudack C, Steinhoff M, Mooren F, Buddenkotte J, Becker K, von Eiff C, Sachse F.

Clin Exp Allergy. 2007 Jul;37(7):1009-22.


LIGR, a protease-activated receptor-2-derived peptide, enhances skin pigmentation without inducing inflammatory processes.

Lin CB, Chen N, Scarpa R, Guan F, Babiarz-Magee L, Liebel F, Li WH, Kizoulis M, Shapiro S, Seiberg M.

Pigment Cell Melanoma Res. 2008 Apr;21(2):172-83. doi: 10.1111/j.1755-148X.2008.00441.x.


PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.

Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.

J Physiol. 2004 Aug 1;558(Pt 3):913-25. Epub 2004 Jun 11.


Trypsin induces epidermal proliferation and inflammation in murine skin.

Meyer-Hoffert U, Rogalski C, Seifert S, Schmeling G, Wingertszahn J, Proksch E, Wiedow O.

Exp Dermatol. 2004 Apr;13(4):234-41.


Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems.

Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3279-89. Epub 2007 Aug 31.


Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2.

Stenton GR, Nohara O, Déry RE, Vliagoftis H, Gilchrist M, Johri A, Wallace JL, Hollenberg MD, Moqbel R, Befus AD.

J Pharmacol Exp Ther. 2002 Aug;302(2):466-74.


Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea.

Abey HT, Fairlie DP, Moffatt JD, Balzary RW, Cocks TM.

J Pharmacol Exp Ther. 2006 May;317(2):598-605. Epub 2006 Jan 24.


2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist.

McGuire JJ, Saifeddine M, Triggle CR, Sun K, Hollenberg MD.

J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31. Epub 2004 Feb 19.


Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

Corvera CU, Déry O, McConalogue K, Böhm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW.

J Clin Invest. 1997 Sep 15;100(6):1383-93.


Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis.

Tsujii K, Andoh T, Ui H, Lee JB, Kuraishi Y.

J Pharmacol Sci. 2009 Mar;109(3):388-95. Epub 2009 Mar 7.


Influence of dexamethasone on protease-activated receptor 2-mediated responses in the airways.

Saleh SM, Mann TS, Peters T, Betts RJ, Henry PJ.

J Pharmacol Exp Ther. 2008 Feb;324(2):622-30. Epub 2007 Nov 14.


Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle.

Chambers LS, Black JL, Poronnik P, Johnson PR.

Am J Physiol Lung Cell Mol Physiol. 2001 Dec;281(6):L1369-78.

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